serpine2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: serpine2provided by ZNC
Official Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-848
See related: Ensembl:ENSDARG00000029353 AllianceGenome:ZFIN:ZDB-GENE-040426-848
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55929
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and negative regulation of plasminogen activation. Predicted to be active in extracellular space. Is expressed in midbrain hindbrain boundary; neural plate; olfactory system; otic vesicle; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (43241915..43283959, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (43360937..43402981, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc70d07.y1 (e-PCR)
- UniSTS:194306

G45324 (e-PCR)
- UniSTS:106126

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glia-derived nexin

Names: serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200184.1 → NP_956478.1 glia-derived nexin precursor

See identical proteins and their annotated locations for NP_956478.1

Status: PROVISIONAL

Source sequence(s)

BC045498

UniProtKB/TrEMBL

B2GNH1, F6NW50, Q7ZVL5

Related

ENSDARP00000041676.6, ENSDART00000041677.8

Conserved Domains (1) summary

cd02051
Location:26 → 395

PAI-1_nexin-1; Plasminogen activator inhibitor-1_like. Plasminogen activator inhibitor-1 (PAI-1) is the primary, fast-acting inhibitor of plasminogen activators. It is often bound to vitronectin, an abundant component of the extracellular matrix in many tissues. ...