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    msi2a musashi RNA-binding protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 100002680, updated on 14-Nov-2024

    Summary

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    Official Symbol
    msi2aprovided by ZNC
    Official Full Name
    musashi RNA-binding protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-25
    See related
    Ensembl:ENSDARG00000033901 AllianceGenome:ZFIN:ZDB-GENE-030826-25
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    msi2; cb746; fi47b09; wu:fb02d08; wu:fi32d12; wu:fi47b09
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in central nervous system development and regulation of translation. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; diencephalon; hindbrain; tegmentum; and telencephalon. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See msi2a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (37500186..37784862)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (37556399..37841104)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:dkey-65j4.2 Neighboring gene A kinase (PRKA) anchor protein 1a Neighboring gene uncharacterized LOC137490697 Neighboring gene uncharacterized LOC103911773 Neighboring gene nucleolar protein 58-like Neighboring gene nucleolar protein 58-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants. Hochgreb-Hägele T, et al. Stem Cells, 2014 Feb. PMID 24420905, Free PMC Article
    2. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. Quach HN, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840430, Free PMC Article
    3. A spinal organ of proprioception for integrated motor action feedback. Picton LD, et al. Neuron, 2021 Apr 7. PMID 33577748
    4. Lef1-dependent hypothalamic neurogenesis inhibits anxiety. Xie Y, et al. PLoS Biol, 2017 Aug. PMID 28837622, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55422

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein Musashi homolog 2a
    Names
    musashi homolog 2
    musashi homolog 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320102.1 → NP_001307031.1  RNA-binding protein Musashi homolog 2a

      Status: VALIDATED

      Source sequence(s)
      CK027672, CR931806, EH471460
      UniProtKB/TrEMBL
      F6NI68, F6P9C3, Q7ZW10
      Related
      ENSDARP00000123512.1, ENSDART00000132096.3
      Conserved Domains (3) summary
      COG0724
      Location:2 → 162
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:23 → 97
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      37500186..37784862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305537.4 → XP_009303812.1  RNA-binding protein Musashi homolog 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M3AX32
      Conserved Domains (3) summary
      COG0724
      Location:2 → 162
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:23 → 97
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394796.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      95171..263204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395293.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      46658..163641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212796.1: Suppressed sequence

      Description
      NM_212796.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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