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    tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [ Danio rerio (zebrafish) ]

    Gene ID: 566547, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tab3provided by ZNC
    Official Full Name
    TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-408
    See related
    Ensembl:ENSDARG00000062063 AllianceGenome:ZFIN:ZDB-GENE-060503-408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    map3k7ip3; map3k7ip3l; si:dkey-30h22.6; si:ch211-232d19.8
    Summary
    Predicted to enable kinase activity; metal ion binding activity; and ubiquitin binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within phosphorylation. Orthologous to human TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tab3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18545506..18562979)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18509827..18527273)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene nexilin (F actin binding protein) Neighboring gene transmembrane protein 47 Neighboring gene proline rich Gla (G-carboxyglutamic acid) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
    2. New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. Tseng LC, et al. PLoS One, 2014. PMID 24714733, Free PMC Article
    3. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Names
    TAK1-binding protein 3
    mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045105.1 → NP_001038570.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

      See identical proteins and their annotated locations for NP_001038570.1

      Status: PROVISIONAL

      Source sequence(s)
      BX247907
      UniProtKB/TrEMBL
      Q1LY04
      Related
      ENSDARP00000083707.5, ENSDART00000089274.7
      Conserved Domains (3) summary
      smart00547
      Location:547 → 570
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:10 → 51
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:548 → 567
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      18545506..18562979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478287.2 → XP_021333962.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQZ1
      Related
      ENSDARP00000148312.1, ENSDART00000191398.1
      Conserved Domains (4) summary
      smart00547
      Location:523 → 546
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:10 → 51
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:524 → 543
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl27975
      Location:112 → 423
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    Nucleotide Protein
    Heading Accession and Version

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