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    epha6 eph receptor A6 [ Danio rerio (zebrafish) ]

    Gene ID: 100005538, updated on 2-Nov-2024

    Summary

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    Official Symbol
    epha6provided by ZNC
    Official Full Name
    eph receptor A6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090311-43
    See related
    Ensembl:ENSDARG00000022971 AllianceGenome:ZFIN:ZDB-GENE-090311-43
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-247c17.1
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to act upstream of or within cell surface receptor protein tyrosine kinase signaling pathway and protein phosphorylation. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See epha6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (33969033..34200315)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (33236455..33467747)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene NOP2/Sun RNA methyltransferase 3 Neighboring gene uncharacterized LOC137490021 Neighboring gene microRNA 734 Neighboring gene uncharacterized LOC137495566 Neighboring gene uncharacterized LOC137495567 Neighboring gene ARF like GTPase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Brain Regeneration Resembles Brain Cancer at Its Early Wound Healing Stage and Diverges From Cancer Later at Its Proliferation and Differentiation Stages. Demirci Y, et al. Front Cell Dev Biol, 2022. PMID 35223842, Free PMC Article
    2. A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas. Marcelli F, et al. PLoS One, 2014. PMID 24945320, Free PMC Article
    3. BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Shi W, et al. J Immunol, 2019 Nov 1. PMID 31562209
    4. Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Rabinowitz JS, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096348, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPHA6, a gene implicated in retinal axon guidance, is one of HMX1 targets in eye development.
      Title: A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 6
    XP_001344560.5
    XP_005159987.1
    XP_021326891.1
    XP_021329588.1
    XP_068075251.1
    XP_068075252.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      33969033..34200315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159930.4 → XP_005159987.1  ephrin type-A receptor 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B746, F6P3V1
      Related
      ENSDARP00000121462.2, ENSDART00000146530.4
      Conserved Domains (8) summary
      smart00454
      Location:913 → 980
      SAM; Sterile alpha motif
      cd10484
      Location:25 → 198
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
      cd00063
      Location:435 → 526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:618 → 889
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:325 → 419
      fn3; Fibronectin type III domain
      pfam07714
      Location:623 → 885
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:566 → 618
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl15755
      Location:916 → 979
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_001344524.8 → XP_001344560.5  ephrin type-A receptor 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M1PSW4, F1REM5
      Related
      ENSDARP00000042983.5, ENSDART00000042984.7
      Conserved Domains (8) summary
      smart00454
      Location:908 → 975
      SAM; Sterile alpha motif
      cd10484
      Location:25 → 198
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
      cd00063
      Location:435 → 526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:618 → 884
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:325 → 419
      fn3; Fibronectin type III domain
      pfam07714
      Location:623 → 880
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:566 → 618
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl15755
      Location:911 → 974
      SAM_superfamily; SAM (Sterile alpha motif )

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394495.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      114217..192372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471216.2 → XP_021326891.1  ephrin type-A receptor 6 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PX89
      Conserved Domains (1) summary
      cl02704
      Location:29 → 202
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395220.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      23726..253995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219150.1 → XP_068075251.1  ephrin type-A receptor 6 isoform X4

    2. XM_021473913.1 → XP_021329588.1  ephrin type-A receptor 6 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PRD4
      Conserved Domains (6) summary
      cd00063
      Location:382 → 473
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:565 → 831
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:272 → 366
      fn3; Fibronectin type III domain
      pfam14575
      Location:510 → 565
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1 → 145
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl15755
      Location:858 → 921
      SAM_superfamily; SAM (Sterile alpha motif )

    3. XM_068219151.1 → XP_068075252.1  ephrin type-A receptor 6 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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