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    ier2a immediate early response 2a [ Danio rerio (zebrafish) ]

    Gene ID: 797137, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ier2aprovided by ZNC
    Official Full Name
    immediate early response 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9126
    See related
    Ensembl:ENSDARG00000099195 AllianceGenome:ZFIN:ZDB-GENE-030131-9126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ier2; fb01b03; wu:fb01b03
    Summary
    Acts upstream of or within several processes, including Kupffer's vesicle development; cilium assembly; and determination of left/right symmetry. Located in nucleus. Is expressed in several structures, including axial chorda mesoderm; forebrain neural rod; midbrain hindbrain boundary; otic placode; and tail bud. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human IER2 (immediate early response 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ier2a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (33761549..33762730)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (33629936..33631114)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 29 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing a Neighboring gene calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a Neighboring gene alkB homolog 7 Neighboring gene general transcription factor IIF, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxicity assessment of atmospheric particulate matter in the Mediterranean and Black Seas open waters. Mesquita SR, et al. Sci Total Environ, 2016 Mar 1. PMID 26745302
    2. Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona). Mesquita SR, et al. Environ Sci Pollut Res Int, 2017 Jun. PMID 28508335
    3. FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1. Hong SK, et al. Proc Natl Acad Sci U S A, 2009 Feb 17. PMID 19164561, Free PMC Article
    4. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Mesquita SR, et al. Environ Pollut, 2015 Nov. PMID 26298234
    5. Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Kenyon A, et al. Sci Rep, 2017 Jul 26. PMID 28747644, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Kupffer's vesicle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    immediate early response gene 2 protein
    Names
    immediate early response 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142583.3 → NP_001136055.2  immediate early response gene 2 protein

      Status: VALIDATED

      Source sequence(s)
      EH483632, EH510074, LO018483
      UniProtKB/Swiss-Prot
      B7SXM5
      UniProtKB/TrEMBL
      A0A0M3HEM8, A0A8M1NQN6
      Related
      ENSDARP00000135138.1, ENSDART00000169337.2
      Conserved Domains (1) summary
      pfam05760
      Location:1 → 97
      IER; Immediate early response protein (IER)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      33761549..33762730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7SXM5.1 GenPept UniProtKB/Swiss-Prot:B7SXM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials