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    pycr3 pyrroline-5-carboxylate reductase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 560682, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pycr3provided by ZNC
    Official Full Name
    pyrroline-5-carboxylate reductase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-244
    See related
    Ensembl:ENSDARG00000015236 AllianceGenome:ZFIN:ZDB-GENE-041014-244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pycrl; si:dkey-235d18.3
    Summary
    Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within proline biosynthetic process. Predicted to be located in cytosol. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pycr3 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (52529051..52541661)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (52723477..52735896)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene GDP-L-fucose synthase, tandem duplicate 1 Neighboring gene GDP-L-fucose synthase, tandem duplicate 2 Neighboring gene si:ch211-221n20.8 Neighboring gene eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) Neighboring gene collagen alpha-1(I) chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress. Kuo ML, et al. Sci Rep, 2016 Jan 6. PMID 26733354, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-proline biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pyrroline-5-carboxylate reductase 3
    Names
    P5C reductase 3
    P5CR 3
    pyrroline-5-carboxylate reductase-like protein
    NP_001038403.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044938.1 → NP_001038403.1  pyrroline-5-carboxylate reductase 3

      See identical proteins and their annotated locations for NP_001038403.1

      Status: PROVISIONAL

      Source sequence(s)
      AL929003
      UniProtKB/Swiss-Prot
      Q05AI4, Q5SPD7
      Related
      ENSDARP00000011713.7, ENSDART00000002787.10
      Conserved Domains (3) summary
      PLN02688
      Location:20 → 283
      PLN02688; pyrroline-5-carboxylate reductase
      pfam03807
      Location:22 → 114
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:176 → 280
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      52529051..52541661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_011007687.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SPD7.1 GenPept UniProtKB/Swiss-Prot:Q5SPD7

    Gene LinkOut

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