cfap52 cilia and flagella associated protein 52 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cfap52provided by ZNC
Official Full Name: cilia and flagella associated protein 52provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-296
See related: Ensembl:ENSDARG00000101679 AllianceGenome:ZFIN:ZDB-GENE-050522-296
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdr16; fj15f10; wu:fj15f10; zgc:111988; si:dkey-28k21.1
Summary: Predicted to be located in axoneme and motile cilium. Is expressed in nervous system and pronephros. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human CFAP52 (cilia and flagella associated protein 52). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (19667619..19683364, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (23196298..23212043, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wdr16 can be considered a differentiation marker of kinocilia-bearing cells. In the brain, it appears to be functionally related to water homeostasis or osmoregulation.(Wdr16, Danio Rerio)
Title: Biosynthesis of Wdr16, a marker protein for kinocilia-bearing cells, starts at the time of kinocilia formation in rat, and wdr16 gene knockdown causes hydrocephalus in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cilia- and flagella-associated protein 52

Names: WD repeat domain 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020639.1 → NP_001018475.1 cilia- and flagella-associated protein 52

See identical proteins and their annotated locations for NP_001018475.1

Status: PROVISIONAL

Source sequence(s)

BC095635

UniProtKB/TrEMBL

Q502N0

Related

ENSDARP00000138481.1, ENSDART00000158041.2

Conserved Domains (4) summary

COG2319
Location:164 → 605

WD40; WD40 repeat [General function prediction only]

cd00200
Location:324 → 612

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:372 → 412

7WD40; WD40 repeat [structural motif]

cl02567
Location:59 → 398

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...