U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gucy2f guanylate cyclase 2F, retinal [ Danio rerio (zebrafish) ]

    Gene ID: 140424, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gucy2fprovided by ZNC
    Official Full Name
    guanylate cyclase 2F, retinalprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-011128-7
    See related
    Ensembl:ENSDARG00000025504 AllianceGenome:ZFIN:ZDB-GENE-011128-7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gc1; RETGC-1
    Summary
    Enables guanylate cyclase activity. Acts upstream of or within photoreceptor cell outer segment organization and visual perception. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in olfactory epithelium; olfactory receptor cell; retina; and retinal outer nuclear layer. Used to study Leber congenital amaurosis. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gucy2f in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (29359745..29382011)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (29426865..29451008)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein 2a Neighboring gene si:dkey-52l18.4 Neighboring gene tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) Neighboring gene serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis. Stiebel-Kalish H, et al. Eur J Hum Genet, 2012 Aug. PMID 22378290, Free PMC Article
    2. Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved. Gao D, et al. Toxicol Sci, 2017 May 1. PMID 28329817
    3. Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Rätscho N, et al. Biochim Biophys Acta, 2009 Jun. PMID 19168097
    4. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. Brockerhoff SE, et al. J Neurosci, 2003 Jan 15. PMID 12533607, Free PMC Article
    5. Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration. Morris AC, et al. Invest Ophthalmol Vis Sci, 2011 Apr 6. PMID 21217106, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gucy2f knockdown resulted in significantly lower vision.
      Title: Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within photoreceptor cell outer segment organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    retinal guanylyl cyclase 2
    Names
    guanylyl cyclase 1
    NP_571939.2
    XP_009289889.1
    XP_017214686.1
    XP_021337004.1
    XP_068069554.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131864.2 → NP_571939.2  retinal guanylyl cyclase 2

      See identical proteins and their annotated locations for NP_571939.2

      Status: PROVISIONAL

      Source sequence(s)
      BX537138
      UniProtKB/TrEMBL
      B3DHF2, B3DHH4
      Related
      ENSDARP00000109090.2, ENSDART00000126196.4
      Conserved Domains (4) summary
      cd06371
      Location:59 → 440
      PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      smart00044
      Location:850 → 1042
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:551 → 816
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam07701
      Location:825 → 870
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      29359745..29382011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017359197.3 → XP_017214686.1  retinal guanylyl cyclase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z295, F1QWF7
      Related
      ENSDARP00000090689.4, ENSDART00000099916.5
      Conserved Domains (7) summary
      cd06371
      Location:59 → 440
      PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      smart00044
      Location:850 → 1042
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:551 → 816
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam00211
      Location:876 → 1063
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:76 → 416
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:825 → 870
      HNOBA; Heme NO binding associated
      pfam07714
      Location:569 → 806
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_021481329.2 → XP_021337004.1  retinal guanylyl cyclase 2 isoform X1

      UniProtKB/TrEMBL
      B3DHF2, B3DHH4
      Conserved Domains (4) summary
      cd06371
      Location:59 → 440
      PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      smart00044
      Location:850 → 1042
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:551 → 816
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam07701
      Location:825 → 870
      HNOBA; Heme NO binding associated

    3. XM_068213453.1 → XP_068069554.1  retinal guanylyl cyclase 2 isoform X1

    4. XM_009291614.4 → XP_009289889.1  retinal guanylyl cyclase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3APR2
      Conserved Domains (7) summary
      cd06371
      Location:59 → 440
      PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      smart00044
      Location:850 → 1042
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:551 → 816
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam00211
      Location:876 → 1063
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:76 → 416
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:825 → 870
      HNOBA; Heme NO binding associated
      pfam07714
      Location:569 → 806
      Pkinase_Tyr; Protein tyrosine kinase

    RNA

    1. XR_011006330.1 RNA Sequence

    2. XR_011006331.1 RNA Sequence

    3. XR_011006329.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.