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    arhgef2b rho/rac guanine nucleotide exchange factor (GEF) 2b [ Danio rerio (zebrafish) ]

    Gene ID: 561276, updated on 2-Nov-2024

    Summary

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    Official Symbol
    arhgef2bprovided by ZNC
    Official Full Name
    rho/rac guanine nucleotide exchange factor (GEF) 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030717-1
    See related
    Ensembl:ENSDARG00000075819 AllianceGenome:ZFIN:ZDB-GENE-030717-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arhgef2; fj11d04; wu:fj11d04; si:ch211-198o19.3
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of neuron differentiation; and regulation of Rho protein signal transduction. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoskeleton and ruffle membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See arhgef2b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (6864633..6936289)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (6923838..6992209)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 236 Neighboring gene myelin basic protein b Neighboring gene phosphomevalonate kinase Neighboring gene ELL associated factor 1 Neighboring gene Bardet-Biedl syndrome 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryonic exposure to an aqueous coal dust extract results in gene expression alterations associated with the development and function of connective tissue and the hematological system, immunological and inflammatory disease, and cancer in zebrafish. Caballero-Gallardo K, et al. Metallomics, 2018 Mar 1. PMID 29485154
    2. Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis. Lu FI, et al. FASEB J, 2019 Sep. PMID 31199673
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 2
    Names
    rho/rac guanine nucleotide exchange factor (GEF) 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      6864633..6936289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_684678.10 → XP_689770.5  rho guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8N7TDR5, E7F4U1
      Related
      ENSDARP00000072768.5, ENSDART00000078306.7
      Conserved Domains (4) summary
      cd00029
      Location:47 → 92
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:244 → 438
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam00169
      Location:481 → 581
      PH; PH domain
      cl17171
      Location:478 → 595
      PH-like; Pleckstrin homology-like domain

    2. XM_005157849.5 → XP_005157906.1  rho guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B448
      Conserved Domains (4) summary
      cd00029
      Location:47 → 92
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:243 → 437
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam00169
      Location:480 → 580
      PH; PH domain
      cl17171
      Location:477 → 594
      PH-like; Pleckstrin homology-like domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394952.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      41150..111997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472949.2 → XP_021328624.1  rho guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PUS2
      Conserved Domains (3) summary
      cd00029
      Location:47 → 92
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:244 → 438
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:478 → 595
      PH-like; Pleckstrin homology-like domain

    2. XM_021472950.2 → XP_021328625.1  rho guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q5I4
      Conserved Domains (3) summary
      cd00029
      Location:47 → 92
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:243 → 437
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:477 → 594
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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