U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gbp1 guanylate binding protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 436615, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gbp1provided by ZNC
    Official Full Name
    guanylate binding protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-32
    See related
    Ensembl:ENSDARG00000038668 AllianceGenome:ZFIN:ZDB-GENE-040718-32
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92185; wu:fd36d06
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within thyroid gland development. Is expressed in thyroid follicle. Orthologous to several human genes including GBP1 (guanylate binding protein 1); GBP2 (guanylate binding protein 2); and GBP3 (guanylate binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gbp1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (42020915..42035314, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (42171497..42185901, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene helicase with zinc finger 2b Neighboring gene guanylate binding protein 2 Neighboring gene centrosome and spindle pole associated protein 1b Neighboring gene valosin containing protein (p97)/p47 complex interacting protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis. Yang RM, et al. Genet Med, 2021 Oct. PMID 34194003, Free PMC Article
    2. Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Jin T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Aug. PMID 23908027, Free PMC Article
    3. Analysis of interferon gamma protein expression in zebrafish (Danio rerio). Yoon S, et al. Fish Shellfish Immunol, 2016 Oct. PMID 27539703
    4. SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation. Cai H, et al. Mol Ther, 2023 Mar 1. PMID 36523164, Free PMC Article
    5. Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. Rajshekar S, et al. Elife, 2018 Nov 28. PMID 30484769, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A GBP1 protein was identified contains an N-terminal GTPase domain and a helical domain.
      Title: Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    guanylate-binding protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002343.1 → NP_001002343.1  guanylate-binding protein 1

      See identical proteins and their annotated locations for NP_001002343.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075920
      UniProtKB/TrEMBL
      A0A8M2BJ59, Q6DHP7
      Related
      ENSDARP00000056459.5, ENSDART00000056460.7
      Conserved Domains (2) summary
      pfam02841
      Location:283 → 579
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21455
      Location:18 → 281
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      42020915..42035314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171375.5 → XP_005171432.1  guanylate-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005171432.1

      UniProtKB/TrEMBL
      A0A8M2BJ59, Q6DHP7
      Conserved Domains (2) summary
      pfam02841
      Location:283 → 579
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21455
      Location:18 → 281
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools