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    dnm1a dynamin 1a [ Danio rerio (zebrafish) ]

    Gene ID: 100307098, updated on 14-Nov-2024

    Summary

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    Official Symbol
    dnm1aprovided by ZNC
    Official Full Name
    dynamin 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-27
    See related
    Ensembl:ENSDARG00000010042 AllianceGenome:ZFIN:ZDB-GENE-081104-27
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dnm1; si:dkey-246l19.2
    Summary
    Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within neuron projection morphogenesis and regulation of skeletal muscle fiber development. Predicted to be active in several cellular components, including microtubule; plasma membrane; and synapse. Is expressed in liver; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 31A and developmental and epileptic encephalopathy 31B. Orthologous to human DNM1 (dynamin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnm1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (1278046..1421927)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (1223570..1368449)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene bublin coiled coil protein Neighboring gene cdkn1a interacting zinc finger protein 1a Neighboring gene uncharacterized LOC137495542 Neighboring gene microRNA 199-1a Neighboring gene golgin A2 Neighboring gene HAUS augmin-like complex, subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effective generation of transgenic reporter and gene trap lines of the medaka (Oryzias latipes) using the Ac/Ds transposon system. Froschauer A, et al. Transgenic Res, 2012 Feb. PMID 21533666
    2. Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue. Bragato C, et al. J Neurosci Res, 2023 Aug. PMID 37031448
    3. Mitochondria in Embryogenesis: An Organellogenesis Perspective. Arribat Y, et al. Front Cell Dev Biol, 2019. PMID 31824944, Free PMC Article
    4. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Schiffer M, et al. Nat Med, 2015 Jun. PMID 25962121, Free PMC Article
    5. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Pan YX, et al. Aquat Toxicol, 2018 Jun. PMID 29604498

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue.
      Title: Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynamin-1a
    Names
    dynamin 1
    NP_001232894.1
    XP_005168137.1
    XP_021331659.1
    XP_068077167.1
    XP_068077168.1
    XP_068077170.1
    XP_068077171.1
    XP_068077172.1
    XP_068077173.1
    XP_068077174.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001245965.1 → NP_001232894.1  dynamin-1a

      See identical proteins and their annotated locations for NP_001232894.1

      Status: PROVISIONAL

      Source sequence(s)
      EF395230
      UniProtKB/TrEMBL
      E4VNZ2
      Related
      ENSDARP00000133389.1, ENSDART00000159783.2
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78 → 743
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:518 → 628
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656 → 744
      GED; Dynamin GTPase effector domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      1278046..1421927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221066.1 → XP_068077167.1  dynamin-1a isoform X1

      Related
      ENSDARP00000124266.1, ENSDART00000147972.3

    2. XM_068221073.1 → XP_068077174.1  dynamin-1a isoform X6

    3. XM_068221071.1 → XP_068077172.1  dynamin-1a isoform X5

    4. XM_068221067.1 → XP_068077168.1  dynamin-1a isoform X3

    5. XM_068221069.1 → XP_068077170.1  dynamin-1a isoform X4

    6. XM_068221072.1 → XP_068077173.1  dynamin-1a isoform X5

    7. XM_021475984.2 → XP_021331659.1  dynamin-1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q2T8
      Conserved Domains (4) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:518 → 628
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656 → 744
      GED; Dynamin GTPase effector domain

    8. XM_068221070.1 → XP_068077171.1  dynamin-1a isoform X3

    9. XM_005168080.4 → XP_005168137.1  dynamin-1a isoform X7

      UniProtKB/TrEMBL
      A0A8M2BG30
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78 → 743
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:518 → 628
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656 → 744
      GED; Dynamin GTPase effector domain
    Nucleotide Protein
    Heading Accession and Version

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