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    ric3b RIC3 acetylcholine receptor chaperone b [ Danio rerio (zebrafish) ]

    Gene ID: 436654, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ric3bprovided by ZNC
    Official Full Name
    RIC3 acetylcholine receptor chaperone bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040323-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040323-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ric3; zgc:92489
    Summary
    Predicted to enable acetylcholine receptor activity. Predicted to be located in plasma membrane. Is expressed in basal plate midbrain region and tegmentum. Orthologous to human RIC3 (RIC3 acetylcholine receptor chaperone). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See ric3b in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (37480169..37483811)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (36878612..36880521)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene Fanconi anemia group A protein Neighboring gene ribosomal protein L27a Neighboring gene zinc finger protein 276 Neighboring gene zinc finger C3H1 domain-containing protein Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene anoctamin-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. Halevi S, et al. J Biol Chem, 2003 Sep 5. PMID 12821669
    2. Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum. Theisen U, et al. PLoS Biol, 2018 Jan. PMID 29300740, Free PMC Article
    3. Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Ding X, et al. Environ Pollut, 2020 Dec. PMID 32841905
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetylcholine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission, postsynaptic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, cholinergic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein RIC-3b
    Names
    resistance to inhibitors of cholinesterase 3 homolog b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002381.1 → NP_001002381.1  protein RIC-3b precursor

      See identical proteins and their annotated locations for NP_001002381.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076034
      UniProtKB/TrEMBL
      Q6DHE0
      Conserved Domains (1) summary
      pfam15361
      Location:24 → 157
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      37480169..37483811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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