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    epb41l3a erythrocyte membrane protein band 4.1-like 3a [ Danio rerio (zebrafish) ]

    Gene ID: 445478, updated on 2-Nov-2024

    Summary

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    Official Symbol
    epb41l3aprovided by ZNC
    Official Full Name
    erythrocyte membrane protein band 4.1-like 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-8
    See related
    Ensembl:ENSDARG00000002255 AllianceGenome:ZFIN:ZDB-GENE-040822-8
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92004
    Summary
    Predicted to enable actin binding activity and structural molecule activity. Acts upstream of or within regulation of excitatory synapse assembly. Predicted to be located in cytoskeleton. Is expressed in nervous system; optic cup; and trigeminal placode. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human EPB41L3 (erythrocyte membrane protein band 4.1 like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See epb41l3a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (41931535..41986897)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (42055974..42089258, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 28 Neighboring gene transmembrane protein 200C, genome duplicate a Neighboring gene zinc finger and BTB domain containing 14 Neighboring gene DNA topoisomerase I mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 4.1Ba is necessary for glutamatergic synapse formation in the sensorimotor circuit of developing zebrafish. Fierro J Jr, et al. PLoS One, 2018. PMID 30286167, Free PMC Article
    2. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC175018

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of excitatory synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 3a
    Names
    zmp:0000000522

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003987.1 → NP_001003987.1  band 4.1-like protein 3a isoform 1

      See identical proteins and their annotated locations for NP_001003987.1

      Status: VALIDATED

      Source sequence(s)
      BC080246
      UniProtKB/TrEMBL
      A0A8M9PLQ9, E7F0A7, E7F634, Q68EI5
      Related
      ENSDARP00000111490.2, ENSDART00000130310.3
      Conserved Domains (5) summary
      smart00295
      Location:92 → 281
      B41; Band 4.1 homologues
      cd13184
      Location:276 → 369
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:549 → 595
      SAB; SAB domain
      pfam05902
      Location:748 → 825
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:378 → 419
      FA; FERM adjacent (FA)

    2. NM_001430860.1 → NP_001417789.1  band 4.1-like protein 3a isoform 1

      Status: VALIDATED

      Source sequence(s)
      CABZ01109510, CU914596, FO818633
      UniProtKB/TrEMBL
      A0A8M9PLQ9, E7F0A7, E7F634, Q68EI5
      Related
      ENSDARP00000016443.8, ENSDART00000022349.9

    3. NM_001430861.1 → NP_001417790.1  band 4.1-like protein 3a isoform 2

      Status: VALIDATED

      Source sequence(s)
      CABZ01089032, CU914596, FO818633

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      41931535..41986897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217054.1 → XP_068073155.1  band 4.1-like protein 3a isoform X4

    2. XM_021470145.2 → XP_021325820.1  band 4.1-like protein 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M9P5U9
      Conserved Domains (6) summary
      smart00295
      Location:92 → 281
      B41; Band 4.1 homologues
      cd13184
      Location:276 → 384
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:564 → 610
      SAB; SAB domain
      pfam05902
      Location:1064 → 1169
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:393 → 434
      FA; FERM adjacent (FA)
      cl26247
      Location:604 → 780
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    3. XM_021470142.2 → XP_021325817.1  band 4.1-like protein 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9P5U6
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 295
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:475 → 521
      SAB; SAB domain
      pfam05902
      Location:975 → 1080
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:304 → 345
      FA; FERM adjacent (FA)
      cl26247
      Location:515 → 691
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    4. XM_021470144.2 → XP_021325819.1  band 4.1-like protein 3a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PLP9
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 295
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:475 → 521
      SAB; SAB domain
      pfam05902
      Location:975 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:304 → 345
      FA; FERM adjacent (FA)
      cl26247
      Location:515 → 691
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    5. XM_021470150.2 → XP_021325825.1  band 4.1-like protein 3a isoform X5

      UniProtKB/TrEMBL
      A0A8M9PXF4
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 295
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:475 → 521
      SAB; SAB domain
      pfam05902
      Location:859 → 964
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:304 → 345
      FA; FERM adjacent (FA)
      cl26247
      Location:515 → 691
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    6. XM_021470151.2 → XP_021325826.1  band 4.1-like protein 3a isoform X7

      UniProtKB/TrEMBL
      A0A8M9PU07
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 295
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:475 → 521
      SAB; SAB domain
      pfam05902
      Location:859 → 936
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:304 → 345
      FA; FERM adjacent (FA)
      cl26247
      Location:515 → 691
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    7. XM_021470152.2 → XP_021325827.1  band 4.1-like protein 3a isoform X8

      UniProtKB/TrEMBL
      A0A8M9P5V2
      Conserved Domains (5) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 295
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:475 → 521
      SAB; SAB domain
      pfam05902
      Location:790 → 895
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:304 → 345
      FA; FERM adjacent (FA)

    8. XM_068217056.1 → XP_068073157.1  band 4.1-like protein 3a isoform X9

    9. XM_021470143.2 → XP_021325818.1  band 4.1-like protein 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PFY0
      Conserved Domains (6) summary
      smart00295
      Location:3 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:460 → 506
      SAB; SAB domain
      pfam05902
      Location:960 → 1065
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:289 → 330
      FA; FERM adjacent (FA)
      cl26247
      Location:500 → 676
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    10. XM_068217055.1 → XP_068073156.1  band 4.1-like protein 3a isoform X6

    11. XM_021470149.2 → XP_021325824.1  band 4.1-like protein 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M9P5U9
      Conserved Domains (6) summary
      smart00295
      Location:92 → 281
      B41; Band 4.1 homologues
      cd13184
      Location:276 → 384
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:564 → 610
      SAB; SAB domain
      pfam05902
      Location:1064 → 1169
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:393 → 434
      FA; FERM adjacent (FA)
      cl26247
      Location:604 → 780
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    12. XM_021470146.2 → XP_021325821.1  band 4.1-like protein 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M9P5U9
      Conserved Domains (6) summary
      smart00295
      Location:92 → 281
      B41; Band 4.1 homologues
      cd13184
      Location:276 → 384
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:564 → 610
      SAB; SAB domain
      pfam05902
      Location:1064 → 1169
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:393 → 434
      FA; FERM adjacent (FA)
      cl26247
      Location:604 → 780
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    13. XM_068217057.1 → XP_068073158.1  band 4.1-like protein 3a isoform X10

    14. XM_021470147.2 → XP_021325822.1  band 4.1-like protein 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M9P5U9
      Conserved Domains (6) summary
      smart00295
      Location:92 → 281
      B41; Band 4.1 homologues
      cd13184
      Location:276 → 384
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:564 → 610
      SAB; SAB domain
      pfam05902
      Location:1064 → 1169
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:393 → 434
      FA; FERM adjacent (FA)
      cl26247
      Location:604 → 780
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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