ift57 intraflagellar transport 57 homolog (Chlamydomonas) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ift57provided by ZNC
Official Full Name: intraflagellar transport 57 homolog (Chlamydomonas)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040614-1
See related: Ensembl:ENSDARG00000021022 AllianceGenome:ZFIN:ZDB-GENE-040614-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hippi; zgc:111831
Summary: Acts upstream of or within several processes, including cilium organization; epithelial cilium movement involved in extracellular fluid movement; and photoreceptor cell maintenance. Predicted to be located in ciliary basal body. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi apparatus; cilium; and microtubule organizing center. Is expressed in head and retina. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XVIII. Orthologous to human IFT57 (intraflagellar transport 57). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (42200413..42210485)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (42350995..42361067)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFT proteins play a conserved role in cilia formation and planar cell polarity in zebrafish
Title: Intraflagellar transport proteins are essential for cilia formation and for planar cell polarity.
Zebrafish IFT mutants also exhibited no dramatic changes in the craniofacial skeleton, somite formation, or motor neuron patterning.
Title: Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: intraflagellar transport protein 57 homolog

Names: axonemal transport protein; curly

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001832.1 → NP_001001832.1 intraflagellar transport protein 57 homolog

See identical proteins and their annotated locations for NP_001001832.1

Status: PROVISIONAL

Source sequence(s)

AY618924

UniProtKB/Swiss-Prot

Q502T5, Q56HB0, Q6IVW0, Q6J504

Related

ENSDARP00000013774.8, ENSDART00000012919.10

Conserved Domains (2) summary

pfam10498
Location:20 → 379

IFT57; Intra-flagellar transport protein 57

cl19219
Location:272 → 372

DUF342; Protein of unknown function (DUF342)