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    gabrr2b gamma-aminobutyric acid type A receptor subunit rho2b [ Danio rerio (zebrafish) ]

    Gene ID: 569032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gabrr2bprovided by ZNC
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit rho2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-174
    See related
    Ensembl:ENSDARG00000014057 AllianceGenome:ZFIN:ZDB-GENE-041014-174
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-181i3.1
    Summary
    Predicted to enable GABA-A receptor activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in eye; forebrain; midbrain; and telencephalon. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gabrr2b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (1158462..1174288, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (1137636..1153440, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho1 Neighboring gene ubiquitin-conjugating enzyme E2, J1 Neighboring gene uncharacterized LOC103909286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos. Raftery TD, et al. Neurotoxicol Teratol, 2015 May-Jun. PMID 25733401
    2. Characterization of zebrafish GABA(A) receptor subunits. Sadamitsu K, et al. Sci Rep, 2021 Mar 18. PMID 33737538, Free PMC Article
    3. Chronic Exposure to Oxazepam Pollution Produces Tolerance to Anxiolytic Effects in Zebrafish (Danio rerio). Vossen LE, et al. Environ Sci Technol, 2020 Feb 4. PMID 31934760
    4. Characterization of the γ-aminobutyric acid signaling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction. Cocco A, et al. Neuroscience, 2017 Feb 20. PMID 27453477
    5. Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. Lee SLJ, et al. BMC Genomics, 2017 Jul 24. PMID 28738802, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit rho-2
    Names
    gamma-aminobutyric acid (GABA) A receptor, rho 2b
    gamma-aminobutyric acid (GABA) receptor, rho 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      1158462..1174288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_692394.9 → XP_697486.2  gamma-aminobutyric acid receptor subunit rho-2 isoform X2

      UniProtKB/TrEMBL
      A0A0A0MPE6, A0A8N7TEK4
      Related
      ENSDARP00000007445.9, ENSDART00000023304.11
      Conserved Domains (3) summary
      TIGR00860
      Location:55 → 463
      LIC; Cation transporter family protein
      pfam02931
      Location:56 → 261
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:268 → 460
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. XM_068215604.1 → XP_068071705.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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