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    gcfc2 GC-rich sequence DNA-binding factor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 559280, updated on 14-Nov-2024

    Summary

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    Official Symbol
    gcfc2provided by ZNC
    Official Full Name
    GC-rich sequence DNA-binding factor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-19
    See related
    Ensembl:ENSDARG00000079020 AllianceGenome:ZFIN:ZDB-GENE-080204-19
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171819
    Summary
    Predicted to enable DNA binding activity. Predicted to act upstream of or within mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human GCFC2 (GC-rich sequence DNA-binding factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gcfc2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (32531928..32551259)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (32579405..32599142)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488118 Neighboring gene grainyhead-like transcription factor 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b Neighboring gene uncharacterized LOC108179784 Neighboring gene eva-1 homolog A (C. elegans)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Srag Regulates Autophagy via Integrating into a Preexisting Autophagy Pathway in Testis. Cheng Y, et al. Mol Biol Evol, 2021 Jan 4. PMID 32722765, Free PMC Article
    2. Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish. Mishima Y, et al. Genes Cells, 2017 Jul. PMID 28557307
    3. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC171819

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intron Large complex component GCFC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110107.2 → NP_001103577.2  intron Large complex component GCFC2

      Status: VALIDATED

      Source sequence(s)
      CR352331
      UniProtKB/TrEMBL
      A0A8M1NF35
      Related
      ENSDARP00000110163.1, ENSDART00000123399.4
      Conserved Domains (1) summary
      pfam07842
      Location:489 → 685
      GCFC; GC-rich sequence DNA-binding factor-like protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      32531928..32551259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158731.5 → XP_005158788.1  intron Large complex component GCFC2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5P2
      Conserved Domains (1) summary
      pfam07842
      Location:499 → 695
      GCFC; GC-rich sequence DNA-binding factor-like protein

    2. XM_005158732.5 → XP_005158789.1  intron Large complex component GCFC2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5M0
      Conserved Domains (1) summary
      pfam07842
      Location:488 → 684
      GCFC; GC-rich sequence DNA-binding factor-like protein
    Nucleotide Protein Strain
    Heading Accession and Version

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