stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stamprovided by ZNC
Official Full Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-123
See related: Ensembl:ENSDARG00000002127 AllianceGenome:ZFIN:ZDB-GENE-031118-123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55725; wu:fv75b10
Summary: Predicted to enable phosphatidylinositol binding activity and ubiquitin binding activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within protein transport. Predicted to be located in early endosome membrane. Predicted to be part of ESCRT-0 complex. Is expressed in immature eye and nervous system. Orthologous to human STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (31437547..31452606)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (31454242..31469393)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT-0 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal transducing adapter molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200120.1 → NP_956414.1 signal transducing adapter molecule 1

See identical proteins and their annotated locations for NP_956414.1

Status: PROVISIONAL

Source sequence(s)

BC045442

UniProtKB/TrEMBL

Q7ZVR5

Related

ENSDARP00000120829.1, ENSDART00000141170.3

Conserved Domains (4) summary

cd11964
Location:215 → 269

SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1

cd03568
Location:9 → 142

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

pfam03127
Location:306 → 379

GAT; GAT domain

cl23807
Location:393 → 482

WWbp; WW-domain ligand protein