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    nek7 NIMA-related kinase 7 [ Danio rerio (zebrafish) ]

    Gene ID: 445223, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nek7provided by ZNC
    Official Full Name
    NIMA-related kinase 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-136
    See related
    Ensembl:ENSDARG00000056966 AllianceGenome:ZFIN:ZDB-GENE-040801-136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92175; wu:fj68f02; zgc:100962
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of NLRP3 inflammasome complex assembly and positive regulation of telomere maintenance via telomerase. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in centrosome and spindle pole. Predicted to be active in nucleus. Orthologous to human NEK7 (NIMA related kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nek7 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (23105059..23228669, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (23090279..23213889, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type C Neighboring gene uncharacterized LOC137488934 Neighboring gene uncharacterized LOC137489016 Neighboring gene si:dkey-121a9.3 Neighboring gene LIM homeobox 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic landscape of T cells identifies synthetic lethality for T-ALL. O'Meara CP, et al. Commun Biol, 2021 Oct 20. PMID 34671088, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC92175

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NLRP3 inflammasome complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek7
    Names
    NIMA (never in mitosis gene a)-related kinase 7
    NP_001003617.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003617.1 → NP_001003617.1  serine/threonine-protein kinase Nek7

      See identical proteins and their annotated locations for NP_001003617.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081618
      UniProtKB/TrEMBL
      F6NXJ5, Q1LWV2, Q6DEH7
      Related
      ENSDARP00000073991.4, ENSDART00000079536.5
      Conserved Domains (2) summary
      smart00220
      Location:30 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08224
      Location:29 → 290
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      23105059..23228669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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