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    asap1b ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b [ Danio rerio (zebrafish) ]

    Gene ID: 565859, updated on 14-Nov-2024

    Summary

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    Official Symbol
    asap1bprovided by ZNC
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091112-16
    See related
    Ensembl:ENSDARG00000039729 AllianceGenome:ZFIN:ZDB-GENE-091112-16
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    asap2; si:dkey-37o8.2
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within defense response to bacterium and positive regulation of macrophage migration. Predicted to be located in cytoplasm. Is expressed in head. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See asap1b in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (10901418..11051245, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (10761058..10909589, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 49 member Bb Neighboring gene eukaryotic translation elongation factor 1 alpha 1, like 3 Neighboring gene microRNA mir-7147 Neighboring gene GTPase IMAP family member 4 Neighboring gene charged multivesicular body protein 4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration. Cui J, et al. Front Cell Infect Microbiol, 2020. PMID 33194781, Free PMC Article
    2. The Role of ARF6 in Biliary Atresia. Ningappa M, et al. PLoS One, 2015. PMID 26379158, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.
      Title: Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of macrophage migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Names
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    asap1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      10901418..11051245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003201277.6 → XP_003201325.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A2R8PVI8, A0A2R8RMX4, A0A8M1RTJ8
      Related
      ENSDARP00000144883.1, ENSDART00000186494.1
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1024 → 1080
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:561 → 690
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:316 → 422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:600 → 634
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:439 → 555
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:788 → 1012
      Atrophin-1; Atrophin-1 family

    2. XM_009297312.4 → XP_009295587.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ANG5, E7FGT3
      Related
      ENSDARP00000120174.1, ENSDART00000145466.3
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1075 → 1131
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:561 → 690
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:316 → 422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:600 → 634
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:439 → 555
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:789 → 1063
      Atrophin-1; Atrophin-1 family

    3. XM_021470289.2 → XP_021325964.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PM69, E7FGT3
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1076 → 1132
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:562 → 691
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:317 → 423
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:601 → 635
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:440 → 556
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:790 → 1064
      Atrophin-1; Atrophin-1 family

    4. XM_068217167.1 → XP_068073268.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

    5. XM_068217169.1 → XP_068073270.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

    6. XM_009297310.4 → XP_009295585.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AVY1, E7FGT3
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1078 → 1134
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:564 → 693
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:319 → 425
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:603 → 637
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:442 → 558
      ArfGap; Putative GTPase activating protein for Arf
      cl26464
      Location:792 → 1066
      Atrophin-1; Atrophin-1 family

    7. XM_068217168.1 → XP_068073269.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

      Related
      ENSDARP00000148169.1, ENSDART00000191320.1
    Nucleotide Protein Strain
    Heading Accession and Version

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