gpib glucose-6-phosphate isomerase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gpibprovided by ZNC
Official Full Name: glucose-6-phosphate isomerase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020513-3
See related: Ensembl:ENSDARG00000103826 AllianceGenome:ZFIN:ZDB-GENE-020513-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PGI; gpi; pgi-2
Summary: Predicted to enable glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to act upstream of or within carbohydrate derivative metabolic process. Predicted to be located in extracellular space. Predicted to be active in cytosol. Is expressed in several structures, including blastoderm; blastomere; head; heart; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (402038..423921)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (512820..534703)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The differential expression of gpia and gpib in zebrafish suggests partition or divergence of gpi functions between the two duplicates.
Title: Differential expression of zebrafish gpia and gpib during development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate derivative metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucose-6-phosphate isomerase b

Names: glucose phosphate isomerase b

NP_658910.2

EC 5.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144764.2 → NP_658910.2 glucose-6-phosphate isomerase b

See identical proteins and their annotated locations for NP_658910.2

Status: VALIDATED

Source sequence(s)

BC121194, EE689256, EV564297

UniProtKB/TrEMBL

Q0IJ39

Related

ENSDARP00000132071.1, ENSDART00000166345.2

Conserved Domains (3) summary

PRK00179
Location:1 → 549

pgi; glucose-6-phosphate isomerase; Reviewed

cd05015
Location:122 → 285

SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

cd05016
Location:333 → 524

SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...