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    ano1a anoctamin 1, calcium activated chloride channel a [ Danio rerio (zebrafish) ]

    Gene ID: 407698, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ano1aprovided by ZNC
    Official Full Name
    anoctamin 1, calcium activated chloride channel aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121127-3
    See related
    Ensembl:ENSDARG00000102335 AllianceGenome:ZFIN:ZDB-GENE-121127-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ano1
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in fast muscle cell and slow muscle cell. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ano1a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (54322648..54449665, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (54052996..54170389, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene Fas (tnfrsf6)-associated via death domain Neighboring gene zgc:153993 Neighboring gene fibroblast growth factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of neuropeptides and anoctamin 1 in the embryonic and adult zebrafish intestine, revealing neuronal subpopulations and ICC-like cells. Uyttebroek L, et al. Cell Tissue Res, 2013 Nov. PMID 23881406
    2. Ca(2+)-activated Cl(-) channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration. Dayal A, et al. Nat Commun, 2019 Jan 10. PMID 30631052, Free PMC Article
    3. Characterization of lncRNAs involved in cold acclimation of zebrafish ZF4 cells. Jiang P, et al. PLoS One, 2018. PMID 29634734, Free PMC Article
    4. Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Li Z, et al. Environ Pollut, 2020 Jul. PMID 32146360
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that Cl(-) influx through calcium activated chloride channel anoctamin-1 (ANO1) plays an essential role in restricting the width of skeletal-muscle action potentials (APs) by accelerating the repolarisation phase.
      Title: Ca(2+)-activated Cl(-) channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration.
    2. The present results also indicate that the Ano1 antiserum is a selective marker of interstitial cells of Cajal - like cells in the zebrafish intestine revealing a 3-dimensional network.
      Title: Expression of neuropeptides and anoctamin 1 in the embryonic and adult zebrafish intestine, revealing neuronal subpopulations and ICC-like cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin-1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161590.1 → NP_001155062.1  anoctamin-1a

      Status: PROVISIONAL

      Source sequence(s)
      CR318608, CU928764
      UniProtKB/TrEMBL
      A0A8M1NT27
      Conserved Domains (2) summary
      pfam04547
      Location:315 → 889
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:53 → 312
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      54322648..54449665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222213.1 → XP_068078314.1  anoctamin-1a isoform X2

    2. XM_068222212.1 → XP_068078313.1  anoctamin-1a isoform X1

    3. XM_017356841.3 → XP_017212330.1  anoctamin-1a isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z1H3
      Related
      ENSDARP00000138095.1, ENSDART00000167905.2

    4. XM_009303473.4 → XP_009301748.1  anoctamin-1a isoform X4

      UniProtKB/TrEMBL
      A0A8M3AUJ5
      Conserved Domains (2) summary
      pfam04547
      Location:315 → 892
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:53 → 312
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    5. XM_009303471.4 → XP_009301746.1  anoctamin-1a isoform X3

      UniProtKB/TrEMBL
      A0A8M3AUL7
      Conserved Domains (2) summary
      pfam04547
      Location:353 → 930
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:91 → 350
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
    Nucleotide Protein Strain
    Heading Accession and Version

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