rasa1a RAS p21 protein activator (GTPase activating protein) 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rasa1aprovided by ZNC
Official Full Name: RAS p21 protein activator (GTPase activating protein) 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4694
See related: Ensembl:ENSDARG00000035535 AllianceGenome:ZFIN:ZDB-GENE-030131-4694
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rasa1; fd52c05; wu:fd52c05; si:dkey-195m1.3
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within blood vessel development and ephrin receptor signaling pathway. Is expressed in head. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (47862624..47967656)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (47210885..47317381)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rasa1-related arteriovenous malformation is driven by aberrant venous signalling.
Title: rasa1-related arteriovenous malformation is driven by aberrant venous signalling.
overexpression of mTORC1 in endothelial cells exacerbated vascular phenotypes in animals with reduced EPHB4 or RASA1, suggesting a functional EPHB4/RASA1/mTORC1 signaling axis in endothelial cells
Title: RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

fd52c05.x1 (e-PCR)
- UniSTS:195622

fk95g04.x1 (e-PCR)
- UniSTS:201783

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ephrin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ras GTPase-activating protein 1

Names: RAS p21 protein activator 1; RAS p21 protein activator 1a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

47862624..47967656

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301766.4 → XP_009300041.2 ras GTPase-activating protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M3B2S6, F1R3X3

Related

ENSDARP00000051517.6, ENSDART00000051518.7
XM_068221515.1 → XP_068077616.1 ras GTPase-activating protein 1 isoform X2

Related

ENSDARP00000123559.2, ENSDART00000139824.4
XM_021476621.2 → XP_021332296.1 ras GTPase-activating protein 1 isoform X3

UniProtKB/TrEMBL

A0A8M9Q9R0

Conserved Domains (6) summary

cd08400
Location:421 → 546

C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)

cd10354
Location:178 → 254

SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)

cd11788
Location:109 → 167

SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1

cd05391
Location:544 → 875

RasGAP_p120GAP; Ras-GTPase Activating Domain of p120

cd13260
Location:301 → 405

PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

cl15255
Location:7 → 92

SH2; Src homology 2 (SH2) domain