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    ripk4 receptor-interacting serine-threonine kinase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 406351, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ripk4provided by ZNC
    Official Full Name
    receptor-interacting serine-threonine kinase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2042
    See related
    Ensembl:ENSDARG00000043211 AllianceGenome:ZFIN:ZDB-GENE-040426-2042
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pkk; zgc:55705; wu:fj80b10
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in several structures, including EVL; digestive system; ectoderm; epidermis; and peripheral olfactory organ. Orthologous to human RIPK4 (receptor interacting serine/threonine kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ripk4 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (35116168..35152934, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (35172310..35212379, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene exosome component 8 Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene zgc:110006 Neighboring gene NOP2/Sun RNA methyltransferase 5 Neighboring gene POM121 transmembrane nucleoporin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RICE CRISPR: Rapidly increased cut ends by an exonuclease Cas9 fusion in zebrafish. Clements TP, et al. Genesis, 2017 Aug. PMID 28653435, Free PMC Article
    2. Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester. Muto A, et al. J Biol Chem, 2002 Aug 30. PMID 12091384
    3. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article
    4. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    receptor-interacting serine/threonine-protein kinase 4
    Names
    protein kinase PKK
    NP_998243.1
    XP_068079859.1
    XP_068079860.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213078.1 → NP_998243.1  receptor-interacting serine/threonine-protein kinase 4

      See identical proteins and their annotated locations for NP_998243.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045432
      UniProtKB/TrEMBL
      Q8JHU3
      Related
      ENSDARP00000063433.4, ENSDART00000063434.4
      Conserved Domains (5) summary
      smart00219
      Location:26 → 279
      TyrKc; Tyrosine kinase, catalytic domain
      cd00204
      Location:495 → 621
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14025
      Location:25 → 291
      STKc_RIP4_like; Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins
      pfam12796
      Location:505 → 595
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:534 → 564
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      35116168..35152934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223759.1 → XP_068079860.1  receptor-interacting serine/threonine-protein kinase 4 isoform X2

    2. XM_068223758.1 → XP_068079859.1  receptor-interacting serine/threonine-protein kinase 4 isoform X1

      Related
      ENSDARP00000150061.1, ENSDART00000188132.1
    Nucleotide Protein Strain
    Heading Accession and Version

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