fgfr2 fibroblast growth factor receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgfr2provided by ZNC
Official Full Name: fibroblast growth factor receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030323-1
See related: Ensembl:ENSDARG00000058115 AllianceGenome:ZFIN:ZDB-GENE-030323-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fgfr-2; fgfr2b; fgfr2c; fc56c05; wu:fc56c05
Summary: Enables fibroblast growth factor binding activity. Acts upstream of or within several processes, including cell proliferation in midbrain; determination of left/right symmetry; and pectoral fin development. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cranium; digestive system; mesoderm; nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (46298560..46429433, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (46162095..46293000, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fgf22 and Fgfr2b are required for neurogenesis and gliogenesis in the zebrafish forebrain.
Title: Fgf22 and Fgfr2b are required for neurogenesis and gliogenesis in the zebrafish forebrain.
Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafish.[Fgfr2c]
Title: Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafish.
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Title: Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development.
the roles of Fgfr2 signaling in zebrafish left-right asymmetry
Title: A variant of fibroblast growth factor receptor 2 (Fgfr2) regulates left-right asymmetry in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell proliferation in midbrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of liver left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of pancreatic left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pectoral fin development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor receptor 2

NP_001229933.1

EC 2.7.10.1

NP_001229934.1

EC 2.7.10.1

NP_001229935.1

EC 2.7.10.1

NP_840088.2

EC 2.7.10.1

XP_005169609.1

EC 2.7.10.1

XP_068081038.1

EC 2.7.10.1

XP_068081039.1

EC 2.7.10.1

XP_068081040.1

EC 2.7.10.1

XP_068081041.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243004.1 → NP_001229933.1 fibroblast growth factor receptor 2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

CU639430, CU862017, FP102866

UniProtKB/Swiss-Prot

Q8JG38

UniProtKB/TrEMBL

A0A8M1NYP8

Related

ENSDARP00000124761.1, ENSDART00000149125.3

Conserved Domains (7) summary

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:271 → 360

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:174 → 248

IG; Immunoglobulin

smart00410
Location:263 → 359

IG_like; Immunoglobulin like

cd05101
Location:452 → 764

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:477 → 753

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:48 → 125

Ig; Immunoglobulin domain
NM_001243005.1 → NP_001229934.1 fibroblast growth factor receptor 2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks one coding exon and includes another, compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

CU639430, CU862017, FP102866

UniProtKB/Swiss-Prot

Q8JG38

UniProtKB/TrEMBL

A0A8M1P3W6, F1RBT3

Related

ENSDARP00000123845.1, ENSDART00000149602.2

Conserved Domains (5) summary

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:263 → 357

IG_like; Immunoglobulin like

cd05101
Location:450 → 762

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:475 → 751

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:271 → 358

Ig; Immunoglobulin domain
NM_001243006.1 → NP_001229935.1 fibroblast growth factor receptor 2 isoform 4 precursor

See identical proteins and their annotated locations for NP_001229935.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks a coding exon compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

CU639430, CU862017, FP102866

UniProtKB/Swiss-Prot

Q8JG38

UniProtKB/TrEMBL

A4QN31

Related

ENSDARP00000089041.4, ENSDART00000098269.6

Conserved Domains (5) summary

cd05857
Location:75 → 159

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:182 → 271

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00410
Location:174 → 270

IG_like; Immunoglobulin like

cd05101
Location:363 → 675

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:388 → 664

Pkinase_Tyr; Protein tyrosine kinase
NM_178303.3 → NP_840088.2 fibroblast growth factor receptor 2 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternative splice site in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

CU639430, CU862017, FP102866

UniProtKB/Swiss-Prot

Q8JG38

UniProtKB/TrEMBL

A0A8M1PE96, F1RBS5

Related

ENSDARP00000124472.1, ENSDART00000150061.3

Conserved Domains (7) summary

cd05857
Location:164 → 248

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:271 → 360

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

smart00409
Location:174 → 248

IG; Immunoglobulin

smart00410
Location:263 → 359

IG_like; Immunoglobulin like

cd05101
Location:450 → 762

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:475 → 751

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:48 → 125

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

46298560..46429433 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068224940.1 → XP_068081041.1 fibroblast growth factor receptor 2 isoform X5
XM_068224939.1 → XP_068081040.1 fibroblast growth factor receptor 2 isoform X4
XM_068224937.1 → XP_068081038.1 fibroblast growth factor receptor 2 isoform X1
XM_005169552.5 → XP_005169609.1 fibroblast growth factor receptor 2 isoform X3

UniProtKB/Swiss-Prot

Q8JG38

UniProtKB/TrEMBL

A0A8M2BGU2

Conserved Domains (5) summary

cd05857
Location:187 → 271

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:286 → 380

IG_like; Immunoglobulin like

cd05101
Location:471 → 783

PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2

pfam07714
Location:496 → 772

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:294 → 381

Ig; Immunoglobulin domain
XM_068224938.1 → XP_068081039.1 fibroblast growth factor receptor 2 isoform X2