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    nudc nudC nuclear distribution protein [ Danio rerio (zebrafish) ]

    Gene ID: 393893, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nudcprovided by ZNC
    Official Full Name
    nudC nuclear distribution proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-899
    See related
    Ensembl:ENSDARG00000104837 AllianceGenome:ZFIN:ZDB-GENE-040426-899
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56099; zgc:85670
    Summary
    Predicted to enable unfolded protein binding activity. Acts upstream of or within cilium assembly and determination of heart left/right asymmetry. Predicted to be located in microtubule and midbody. Predicted to be active in cytoplasm. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nudc in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (14158095..14169460)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (14295900..14307265)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene keratinocyte differentiation factor 1b Neighboring gene nuclear receptor subfamily 0, group B, member 2b Neighboring gene T-box transcription factor Ta Neighboring gene AT-rich interactive domain 1Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1. Zhang C, et al. Cell Res, 2016 Feb. PMID 26704451, Free PMC Article
    2. Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. Balciuniene J, et al. BMC Genomics, 2013 Sep 14. PMID 24034702, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56099

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of heart left/right asymmetry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear migration protein nudC
    Names
    nuclear distribution gene C homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200919.1 → NP_957213.1  nuclear migration protein nudC

      See identical proteins and their annotated locations for NP_957213.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045909
      UniProtKB/TrEMBL
      Q7ZVD2
      Related
      ENSDARP00000136053.1, ENSDART00000170335.2
      Conserved Domains (3) summary
      cd06492
      Location:174 → 260
      p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
      pfam14050
      Location:7 → 57
      Nudc_N; N-terminal conserved domain of Nudc
      pfam16273
      Location:100 → 158
      NuDC; Nuclear distribution C domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      14158095..14169460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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