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    qars1 glutaminyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 394188, updated on 14-Nov-2024

    Summary

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    Official Symbol
    qars1provided by ZNC
    Official Full Name
    glutaminyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1011
    See related
    Ensembl:ENSDARG00000010316 AllianceGenome:ZFIN:ZDB-GENE-040426-1011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    qars; zgc:56395
    Summary
    Predicted to enable glutamine-tRNA ligase activity. Predicted to be involved in glutaminyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Is expressed in several structures, including brain; digestive system; optic cup; pectoral fin bud; and swim bladder. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See qars1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (46353202..46386060, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (46345457..46378181, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene angiopoietin-like 7 Neighboring gene si:dkey-75a21.2 Neighboring gene proline-rich transmembrane protein 3 Neighboring gene 8-oxoguanine DNA glycosylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004
    2. Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. Tao T, et al. PLoS One, 2013. PMID 23593122, Free PMC Article
    3. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. Waldron AL, et al. PLoS One, 2017. PMID 28934368, Free PMC Article
    4. Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish. Lin SJ, et al. Genet Med, 2021 Oct. PMID 34172899, Free PMC Article
    5. mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Scheldeman C, et al. Neurobiol Dis, 2017 Dec. PMID 28888969

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56395

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutaminyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamine--tRNA ligase
    NP_001410591.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423662.1 → NP_001410591.1  glutamine--tRNA ligase

      Status: VALIDATED

      Source sequence(s)
      CR450703
      Related
      ENSDARP00000060918.4, ENSDART00000060919.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      46353202..46386060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201213.1: Suppressed sequence

      Description
      NM_201213.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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