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    btbd6b BTB (POZ) domain containing 6b [ Danio rerio (zebrafish) ]

    Gene ID: 553533, updated on 2-Nov-2024

    Summary

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    Official Symbol
    btbd6bprovided by ZNC
    Official Full Name
    BTB (POZ) domain containing 6bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030829-65
    See related
    Ensembl:ENSDARG00000032369 AllianceGenome:ZFIN:ZDB-GENE-030829-65
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    btbd6; btbd6a; sb:cb776; zgc:152751; si:dkey-11b8.2
    Summary
    Predicted to be involved in neurogenesis. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including myotome; nervous system; neural crest; neural tube; and otic vesicle. Orthologous to human BTBD6 (BTB domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See btbd6b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (20927827..20932782, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (21028154..21033109, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene creatine kinase, brain b Neighboring gene BRF1 general transcription factor IIIB subunit b Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene rho GTPase-activating protein 1-like Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation. Sobieszczuk DF, et al. Genes Dev, 2010 Jan 15. PMID 20080956, Free PMC Article
    2. Gene expression profiling in zebrafish embryos exposed to diclofenac, an environmental toxicant. De Felice B, et al. Mol Biol Rep, 2012 Mar. PMID 21643954
    3. Reverse genetic analysis of neurogenesis in the zebrafish retina. Pujic Z, et al. Dev Biol, 2006 May 15. PMID 16603149
    4. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Armant O, et al. Dev Biol, 2013 Aug 15. PMID 23684812, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Btbd6a promotes the relocation of Plzf from nucleus to cytoplasm and targets Plzf for ubiquitination and degradation
      Title: A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 6-B
    Names
    BTB (POZ) domain containing 6
    BTB/POZ domain-containing protein 6-A
    gacek

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024815.2 → NP_001019986.1  BTB/POZ domain-containing protein 6-B

      See identical proteins and their annotated locations for NP_001019986.1

      Status: PROVISIONAL

      Source sequence(s)
      BX255905
      UniProtKB/Swiss-Prot
      Q5TZE1
      Related
      ENSDARP00000039906.5, ENSDART00000039907.7
      Conserved Domains (4) summary
      smart00225
      Location:81 → 180
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:186 → 292
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:73 → 176
      BTB; BTB/POZ domain
      pfam08005
      Location:337 → 480
      PHR; PHR domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      20927827..20932782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160494.5 → XP_005160551.1  BTB/POZ domain-containing protein 6-B isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7L0
      Conserved Domains (4) summary
      smart00225
      Location:134 → 233
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:239 → 345
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:126 → 229
      BTB; BTB/POZ domain
      pfam08005
      Location:390 → 533
      PHR; PHR domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395068.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      105952..110908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TZE1.1 GenPept UniProtKB/Swiss-Prot:Q5TZE1

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