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    ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa [ Danio rerio (zebrafish) ]

    Gene ID: 30704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppm1aaprovided by ZNC
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent, 1Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991102-15
    See related
    Ensembl:ENSDARG00000032155 AllianceGenome:ZFIN:ZDB-GENE-991102-15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pp2ca2
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within cartilage development. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppm1aa in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (31545798..31580190)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (31415351..31449740)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene pecanex 4 Neighboring gene dehydrogenase/reductase (SDR family) member 7 Neighboring gene SIX homeobox 6a Neighboring gene SIX homeobox 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of the PP2C family in Caenorhabditis: rapid divergence of the sex-determining protein FEM-2. Stothard P, et al. J Mol Evol, 2002 Feb. PMID 11821919
    2. Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. Yang S, et al. iScience, 2022 Jun 17. PMID 35712083, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1A
    Names
    protein phosphatase type 2C alpha 2
    NP_571504.1
    XP_005156831.1
    XP_005156832.1
    XP_021336193.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131429.1 → NP_571504.1  protein phosphatase 1A

      See identical proteins and their annotated locations for NP_571504.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066510
      UniProtKB/TrEMBL
      A0A8M1P810, Q6NYP6
      Related
      ENSDARP00000070999.5, ENSDART00000076527.7
      Conserved Domains (2) summary
      pfam00481
      Location:22 → 291
      PP2C; Protein phosphatase 2C
      pfam07830
      Location:292 → 368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      31545798..31580190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480518.2 → XP_021336193.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9J2
      Related
      ENSDARP00000152770.1, ENSDART00000185503.1
      Conserved Domains (2) summary
      pfam00481
      Location:22 → 291
      PP2C; Protein phosphatase 2C
      pfam07830
      Location:292 → 368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    2. XM_005156774.5 → XP_005156831.1  protein phosphatase 1A isoform X2

      UniProtKB/TrEMBL
      A0A286Y912, A0A8M2B2W7
      Related
      ENSDARP00000143657.1, ENSDART00000178460.2
      Conserved Domains (2) summary
      cd00143
      Location:23 → 298
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:292 → 368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    3. XM_005156775.5 → XP_005156832.1  protein phosphatase 1A isoform X3

      UniProtKB/TrEMBL
      A0A0R4IYF8, A0A8M2B327
      Related
      ENSDARP00000140697.2, ENSDART00000164590.2
      Conserved Domains (2) summary
      pfam00481
      Location:22 → 291
      PP2C; Protein phosphatase 2C
      pfam07830
      Location:292 → 368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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