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    efna5a ephrin-A5a [ Danio rerio (zebrafish) ]

    Gene ID: 64256, updated on 14-Nov-2024

    Summary

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    Official Symbol
    efna5aprovided by ZNC
    Official Full Name
    ephrin-A5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001128-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-001128-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    L2; cb1080; fl02c06; wu:fl02c06
    Summary
    Predicted to enable ephrin receptor binding activity. Predicted to be involved in several processes, including axon guidance; ephrin receptor signaling pathway; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in side of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including anterior neural keel; immature eye; nervous system; neural plate; and neural tube. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See efna5a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (20548698..20633384)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (20512049..20597382)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkey-30k6.5 Neighboring gene zgc:103482 Neighboring gene growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 Neighboring gene growth arrest and DNA damage-inducible protein GADD45 gamma-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection. Picker A, et al. Development, 1999 Jul. PMID 10357940
    2. Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Kim MJ, et al. Glycobiology, 2007 Feb. PMID 17110391
    3. Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina. Picker A, et al. Development, 2005 Nov. PMID 16236770
    4. Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. Liu Y, et al. J Neurosci, 2004 Jan 14. PMID 14724229, Free PMC Article
    5. Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina. Picker A, et al. PLoS Biol, 2009 Oct. PMID 19823566, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ephrin-A5a; ephrin-A5b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      20548698..20633384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001337352.8 → XP_001337388.4  ephrin-A5b isoform X1

      UniProtKB/TrEMBL
      A0A8M1PZ39
      Conserved Domains (1) summary
      cd10425
      Location:30 → 159
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A

    2. XM_005161235.5 → XP_005161292.1  ephrin-A5b isoform X2

      UniProtKB/TrEMBL
      A0A8M2B861
      Conserved Domains (1) summary
      cd10425
      Location:30 → 159
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A
    Nucleotide Protein
    Heading Accession and Version

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