gsdmeb gasdermin Eb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gsdmebprovided by ZNC
Official Full Name: gasdermin Ebprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7662
See related: Ensembl:ENSDARG00000040485 AllianceGenome:ZFIN:ZDB-GENE-030131-7662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dfna5; dfna5b; fk59f08; zgc:91916; wu:fc41e05; wu:fk59f08
Summary: Acts upstream of or within with a positive effect on pyroptotic inflammatory response. Acts upstream of or within inner ear morphogenesis and regulation of biosynthetic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including hematopoietic system; liver; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (21423394..21442287)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (21619295..21636468)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1beta maturation and gasdermin E-mediated pyroptosis.
Title: The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis.

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General gene information

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Markers

fk59f08.x1 (e-PCR)
- UniSTS:201273

fc41e05.x1 (e-PCR)
- UniSTS:188144

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect pyroptotic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pyroptotic inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gasdermin Eb

Names: deafness, autosomal dominant 5 b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.