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    septin8b septin 8b [ Danio rerio (zebrafish) ]

    Gene ID: 571702, updated on 2-Nov-2024

    Summary

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    Official Symbol
    septin8bprovided by ZNC
    Official Full Name
    septin 8bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070424-3
    See related
    Ensembl:ENSDARG00000014233 AllianceGenome:ZFIN:ZDB-GENE-070424-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sept8b; Septin-8-B; zgc:136574
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in nervous system. Orthologous to human SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See septin8b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (49040190..49063139, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (50052438..50075406, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 5b Neighboring gene sideroflexin 1 Neighboring gene protein phosphatase 2 catalytic subunit alpha a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. sept8a and sept8b mRNA expression in the developing and adult zebrafish. Berger C, et al. Gene Expr Patterns, 2017 Nov. PMID 28414113
    2. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
    3. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425
    4. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. Groh KJ, et al. Gen Comp Endocrinol, 2013 Nov 1. PMID 23968773
    5. Regeneration associated transcriptional signature of retinal microglia and macrophages. Mitchell DM, et al. Sci Rep, 2019 Mar 18. PMID 30886241, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136574

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin-8-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083566.1 → NP_001077035.1  septin-8-B

      See identical proteins and their annotated locations for NP_001077035.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115182
      UniProtKB/Swiss-Prot
      A4FUM1
      Related
      ENSDARP00000026858.7, ENSDART00000021260.9
      Conserved Domains (3) summary
      cd01850
      Location:39 → 307
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:20 → 404
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:334 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      49040190..49063139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169631.4 → XP_005169688.1  septin-8-B isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGW7
      Conserved Domains (3) summary
      cd01850
      Location:61 → 329
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:42 → 426
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:356 → 432
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_021481055.2 → XP_021336730.1  septin-8-B isoform X2

      UniProtKB/TrEMBL
      A0A8M9QP77
      Conserved Domains (2) summary
      cd01850
      Location:26 → 294
      CDC_Septin; CDC/Septin GTPase family
      cl26511
      Location:275 → 407
      Neuromodulin_N; Gap junction protein N-terminal region

    3. XM_068213238.1 → XP_068069339.1  septin-8-B isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4FUM1.1 GenPept UniProtKB/Swiss-Prot:A4FUM1

    Gene LinkOut

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