sp5a Sp5 transcription factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sp5aprovided by ZNC
Official Full Name: Sp5 transcription factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030430-2
See related: Ensembl:ENSDARG00000076571 AllianceGenome:ZFIN:ZDB-GENE-030430-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sp5; bts1; fc39b01; wu:fc39b01
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within mesoderm morphogenesis. Is expressed in brain; margin; and tail bud. Orthologous to human SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (3666393..3671934, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (3694864..3700405, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sp5 transcription factors mediate the downstream responses to Wnt/beta-catenin signaling in several developmental processes in zebrafish.
Title: The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning.

Submit: New GeneRIF Correction

General gene information

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Markers

fb09c06.x1 (e-PCR)
- UniSTS:189980

fk30g07.y1 (e-PCR)
- UniSTS:200785

fc02h08.x1 (e-PCR)
- UniSTS:192089

fc39b01.x1 (e-PCR)
- UniSTS:193750

fc25b11.y1 (e-PCR)
- UniSTS:193242

fj04f02.x1 (e-PCR)
- UniSTS:198364

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mesoderm morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otolith formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor Sp5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_180973.3 → NP_851304.2 transcription factor Sp5a

See identical proteins and their annotated locations for NP_851304.2

Status: VALIDATED

Source sequence(s)

CR394567

UniProtKB/TrEMBL

B0S6I8, B3DH67

Related

ENSDARP00000093674.4, ENSDART00000102900.5

Conserved Domains (2) summary

sd00017
Location:268 → 287

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:309 → 332

zf-H2C2_2; Zinc-finger double domain