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    mcrs1 microspherule protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406557, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mcrs1provided by ZNC
    Official Full Name
    microspherule protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2434
    See related
    Ensembl:ENSDARG00000020840 AllianceGenome:ZFIN:ZDB-GENE-040426-2434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66428; zgc:77376; wu:fj97a11
    Summary
    Predicted to enable G-quadruplex RNA binding activity. Acts upstream of or within cilium assembly and retina layer formation. Predicted to be part of NSL complex. Is expressed in brain; eye; pronephros; and spinal cord. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mcrs1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3367281..3381273, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3299121..3313113, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 2 Neighboring gene sulfite oxidase Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3b Neighboring gene pseudouridine synthase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment. Lee SH, et al. Sci Rep, 2016 Jun 6. PMID 27263857, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MLL1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    microspherule protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213273.1 → NP_998438.1  microspherule protein 1

      See identical proteins and their annotated locations for NP_998438.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065654
      UniProtKB/TrEMBL
      A0A8M1PEX1, Q6P0E3
      Related
      ENSDARP00000023460.6, ENSDART00000002545.8
      Conserved Domains (2) summary
      cd00060
      Location:366 → 455
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:144 → 341
      MCRS_N; N-terminal region of micro-spherule protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      3367281..3381273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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