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    mapk6 mitogen-activated protein kinase 6 [ Danio rerio (zebrafish) ]

    Gene ID: 565830, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mapk6provided by ZNC
    Official Full Name
    mitogen-activated protein kinase 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050420-7
    See related
    Ensembl:ENSDARG00000032103 AllianceGenome:ZFIN:ZDB-GENE-050420-7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    erk3; p97mapk; si:ch211-235f12.1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; otic vesicle; and pectoral fin. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mapk6 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (39171856..39188417, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (39190846..39219557, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene BCL2 like 10 Neighboring gene uncharacterized LOC137488228 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component Neighboring gene tropomodulin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Neurotoxicological effects induced by up-regulation of miR-137 following triclosan exposure to zebrafish (Danio rerio). Liu J, et al. Aquat Toxicol, 2019 Jan. PMID 30496951
    2. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Shi X, et al. Toxicol Sci, 2010 Jun. PMID 20200220
    3. Characterization and expression patterns of the MAPK family in zebrafish. Krens SF, et al. Gene Expr Patterns, 2006 Oct. PMID 16774848
    4. Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish. Wu Q, et al. Sci Total Environ, 2019 Nov 25. PMID 31374495
    5. Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos. Yin J, et al. Environ Toxicol Pharmacol, 2017 Dec. PMID 29102874

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 6
    Names
    extracellular signal-regulated kinase 3
    NP_001039017.1
    XP_017207438.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045552.1 → NP_001039017.1  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_001039017.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ360074
      UniProtKB/TrEMBL
      A0A0R4ID10, F6P883, Q0H1F2
      Related
      ENSDARP00000034206.7, ENSDART00000029549.9
      Conserved Domains (2) summary
      cd07854
      Location:14 → 355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      smart00220
      Location:20 → 316
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      39171856..39188417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351949.3 → XP_017207438.1  mitogen-activated protein kinase 6 isoform X1

      UniProtKB/TrEMBL
      A0A0R4ID10, F6P883, Q0H1F2
      Related
      ENSDARP00000130447.1, ENSDART00000162983.3
      Conserved Domains (2) summary
      cd07854
      Location:14 → 355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      smart00220
      Location:20 → 316
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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