rgl1 ral guanine nucleotide dissociation stimulator-like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgl1provided by ZNC
Official Full Name: ral guanine nucleotide dissociation stimulator-like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1816
See related: Ensembl:ENSDARG00000005989 AllianceGenome:ZFIN:ZDB-GENE-040426-1816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77299
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Orthologous to human RGL1 (ral guanine nucleotide dissociation stimulator like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (19283143..19342111, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (19252726..19311694, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ral guanine nucleotide dissociation stimulator-like 1

Names: ralGDS-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320403.1 → NP_001307332.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

CU984571, EH591632, FP067410

UniProtKB/Swiss-Prot

Q6P112

UniProtKB/TrEMBL

A0A0R4ICN7, A0A8M1P2Z9

Related

ENSDARP00000131072.1, ENSDART00000164780.2

Conserved Domains (3) summary

cd06224
Location:79 → 202

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

cd00153
Location:654 → 739

RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins

cd00155
Location:236 → 505

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_205637.2 → NP_991200.2 ral guanine nucleotide dissociation stimulator-like 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CU984571, FP067410

UniProtKB/Swiss-Prot

Q6P112

UniProtKB/TrEMBL

A0A8M1PET7, A9C3Q2

Related

ENSDARP00000120417.1, ENSDART00000138881.3

Conserved Domains (3) summary

cd06224
Location:109 → 232

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

cd00153
Location:684 → 769

RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins

cd00155
Location:266 → 535

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...