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    pias2 protein inhibitor of activated STAT, 2 [ Danio rerio (zebrafish) ]

    Gene ID: 564149, updated on 14-Nov-2024

    Summary

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    Official Symbol
    pias2provided by ZNC
    Official Full Name
    protein inhibitor of activated STAT, 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060424-1
    See related
    Ensembl:ENSDARG00000092979 AllianceGenome:ZFIN:ZDB-GENE-060424-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    piasx; wu:fi05f09
    Summary
    Predicted to enable SUMO ligase activity and transcription coregulator activity. Predicted to be involved in protein sumoylation and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pias2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41476446..41485229)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (40876293..40885076)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 3 Neighboring gene AT rich interactive domain 3C (BRIGHT-like) Neighboring gene uncharacterized LOC103911098 Neighboring gene eukaryotic translation elongation factor 2, like 2 Neighboring gene FA complementation group G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. Xiong R, et al. J Immunol, 2012 Mar 15. PMID 22345667
    2. The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Meng ZZ, et al. Nat Commun, 2017 Mar 3. PMID 28256502, Free PMC Article
    3. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase PIAS2
    NP_001313410.1
    XP_005165453.1
    XP_005165456.1
    XP_005165457.1
    XP_005165458.1
    XP_068077346.1
    XP_068077347.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326481.1 → NP_001313410.1  E3 SUMO-protein ligase PIAS2

      Status: VALIDATED

      Source sequence(s)
      CR318632
      UniProtKB/TrEMBL
      A0A8M1P805, A2CE48
      Related
      ENSDARP00000122573.1, ENSDART00000142538.3
      Conserved Domains (3) summary
      smart00513
      Location:11 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:341 → 389
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:143 → 281
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      41476446..41485229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165399.5 → XP_005165456.1  E3 SUMO-protein ligase PIAS2 isoform X2

      See identical proteins and their annotated locations for XP_005165456.1

      UniProtKB/TrEMBL
      A0A8M2BCQ4, X1WFJ1
      Conserved Domains (3) summary
      smart00513
      Location:2 → 27
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:332 → 380
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:134 → 272
      PINIT; PINIT domain

    2. XM_068221245.1 → XP_068077346.1  E3 SUMO-protein ligase PIAS2 isoform X3

    3. XM_005165401.5 → XP_005165458.1  E3 SUMO-protein ligase PIAS2 isoform X2

      See identical proteins and their annotated locations for XP_005165458.1

      UniProtKB/TrEMBL
      A0A8M2BCQ4, X1WFJ1
      Conserved Domains (3) summary
      smart00513
      Location:2 → 27
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:332 → 380
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:134 → 272
      PINIT; PINIT domain

    4. XM_005165400.5 → XP_005165457.1  E3 SUMO-protein ligase PIAS2 isoform X2

      See identical proteins and their annotated locations for XP_005165457.1

      UniProtKB/TrEMBL
      A0A8M2BCQ4, X1WFJ1
      Related
      ENSDARP00000128995.2, ENSDART00000153567.3
      Conserved Domains (3) summary
      smart00513
      Location:2 → 27
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:332 → 380
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:134 → 272
      PINIT; PINIT domain

    5. XM_068221246.1 → XP_068077347.1  E3 SUMO-protein ligase PIAS2 isoform X3

      Related
      ENSDARP00000146894.1, ENSDART00000185871.1

    6. XM_005165396.4 → XP_005165453.1  E3 SUMO-protein ligase PIAS2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCP8
      Conserved Domains (3) summary
      smart00513
      Location:11 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:341 → 389
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:143 → 281
      PINIT; PINIT domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395242.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      244668..253464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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