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    pim1 Pim-1 proto-oncogene, serine/threonine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 572469, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pim1provided by ZNC
    Official Full Name
    Pim-1 proto-oncogene, serine/threonine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-139
    See related
    Ensembl:ENSDARG00000100020 AllianceGenome:ZFIN:ZDB-GENE-061013-139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc09e03; zgc:153997
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within camera-type eye morphogenesis and optokinetic behavior. Predicted to be active in cytoplasm. Is expressed in brain and eye. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See pim1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (10305045..10308771)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (10267316..10271042)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-8e10.3 Neighboring gene uncharacterized LOC103911468 Neighboring gene TBC1 domain family, member 22B Neighboring gene uncharacterized LOC101886923

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. IRF2 Cooperates with Phosphoprotein of Spring Viremia of Carp Virus to Suppress Antiviral Response in Zebrafish. Huang W, et al. J Virol, 2022 Nov 23. PMID 36314827, Free PMC Article
    2. Inhibition of the Pim1 oncogene results in diminished visual function. Yin J, et al. PLoS One, 2012. PMID 23300608, Free PMC Article
    3. Comparative analysis of genes regulated by Dzip1/iguana and hedgehog in zebrafish. Arnold CR, et al. Dev Dyn, 2015 Feb. PMID 25476803
    4. Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. Liang F, et al. Biology (Basel), 2023 Mar 31. PMID 37106740, Free PMC Article
    5. Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. Jung IH, et al. Neoplasia, 2015 Jul. PMID 26297436, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153997

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within optokinetic behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase pim-1
    NP_001070859.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077391.1 → NP_001070859.1  serine/threonine-protein kinase pim-1

      See identical proteins and their annotated locations for NP_001070859.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124789
      UniProtKB/TrEMBL
      A0A0R4IGR5, B2GPH4, Q08BC0
      Related
      ENSDARP00000132458.1, ENSDART00000160766.2
      Conserved Domains (2) summary
      pfam00069
      Location:35 → 287
      Pkinase; Protein kinase domain
      cl21453
      Location:34 → 287
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      10305045..10308771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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