lrrc23 leucine rich repeat containing 23 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lrrc23provided by ZNC
Official Full Name: leucine rich repeat containing 23provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-153
See related: Ensembl:ENSDARG00000006174 AllianceGenome:ZFIN:ZDB-GENE-041010-153
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101782
Summary: Acts upstream of or within cilium movement involved in otolith formation. Located in extracellular region. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; pronephric duct; and spinal cord neural keel. Human ortholog(s) of this gene implicated in spermatogenic failure 92. Orthologous to human LRRC23 (leucine rich repeat containing 23). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (20127883..20134012, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (20201540..20207639, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in lrrc23 resulted in a selective otolith formation defect during early ear development.
Title: Radial spoke proteins regulate otolith formation during early zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement involved in otolith formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006054.1 → NP_001006054.1 leucine-rich repeat-containing protein 23

See identical proteins and their annotated locations for NP_001006054.1

Status: PROVISIONAL

Source sequence(s)

BC083278

UniProtKB/TrEMBL

Q5XJM1

Related

ENSDARP00000004624.4, ENSDART00000004871.7

Conserved Domains (3) summary

sd00033
Location:64 → 83

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:194 → 235

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:194 → 251

LRR_8; Leucine rich repeat