U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cnn2 calponin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406658, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cnn2provided by ZNC
    Official Full Name
    calponin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-542
    See related
    Ensembl:ENSDARG00000035858 AllianceGenome:ZFIN:ZDB-GENE-030131-542
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wz2414; zgc:65794; wu:fb36d03; wu:fb93a05
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within regulation of MAPK cascade; regulation of blood vessel endothelial cell migration; and response to steroid hormone. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including central nervous system; digestive system; mesoderm; periderm; and vasculature. Orthologous to human CNN2 (calponin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cnn2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24548252..24554359, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24892601..24898672, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene angiopoietin-like 4 Neighboring gene uncharacterized LOC137487819 Neighboring gene cofactor required for Sp1 transcriptional activation, subunit 7 Neighboring gene CREB regulated transcription coactivator 1a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A critical role for calponin 2 in vascular development. Tang J, et al. J Biol Chem, 2006 Mar 10. PMID 16317011
    2. Tris(1,3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos. Dasgupta S, et al. PeerJ, 2017. PMID 29259843, Free PMC Article
    3. A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Iovine MK, et al. Genomics, 2002 Jun. PMID 12036288
    4. Fine selection of up-regulated genes during ovulation by in vivo induction of oocyte maturation and ovulation in zebrafish. Klangnurak W, et al. Zoological Lett, 2017. PMID 28265462, Free PMC Article
    5. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. Hultqvist G, et al. PLoS One, 2012. PMID 22855693, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    calponin-2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213349.1 → NP_998514.1  calponin-2

      See identical proteins and their annotated locations for NP_998514.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059802
      UniProtKB/TrEMBL
      Q6PBA5
      Related
      ENSDARP00000052060.5, ENSDART00000052061.6
      Conserved Domains (3) summary
      COG5199
      Location:17 → 189
      SCP1; Calponin [Cytoskeleton]
      pfam00307
      Location:28 → 126
      CH; Calponin homology (CH) domain
      pfam00402
      Location:165 → 188
      Calponin; Calponin family repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      24548252..24554359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479618.2 → XP_021335293.1  calponin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q784
      Conserved Domains (2) summary
      pfam00307
      Location:27 → 129
      CH; Calponin homology (CH) domain
      pfam00402
      Location:195 → 218
      Calponin; Calponin family repeat
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools