U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    src v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [ Danio rerio (zebrafish) ]

    Gene ID: 325084, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    srcprovided by ZNC
    Official Full Name
    v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3809
    See related
    Ensembl:ENSDARG00000008107 AllianceGenome:ZFIN:ZDB-GENE-030131-3809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    c-src; fc54g04; p60-Src; sb:cb864; wu:fc54g04
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within posterior lateral line neuromast primordium migration; regulation of vascular permeability; and response to yeast. Predicted to be located in several cellular components, including focal adhesion; mitochondrial inner membrane; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including adaxial cell; central nervous system; musculature system; periderm; and retina. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See src in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (39346930..39455070)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (39453979..39560022)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489145 Neighboring gene potassium voltage-gated channel, subfamily G, member 1 Neighboring gene uncharacterized LOC137489146 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene calcium/calmodulin-dependent protein kinase IGb

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion. Gallardo VE, et al. Dis Model Mech, 2015 Jun. PMID 25810455, Free PMC Article
    2. Low concentrations of 4-ABP promote liver carcinogenesis in human liver cells and a zebrafish model. Lin HD, et al. J Hazard Mater, 2022 Feb 5. PMID 34474361
    3. A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Turro E, et al. Sci Transl Med, 2016 Mar 2. PMID 26936507, Free PMC Article
    4. Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform. Lin HS, et al. Cancers (Basel), 2019 May 28. PMID 31141996, Free PMC Article
    5. Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface. Dergai M, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20659428

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Src-Tks5 pathway is required for neural crest cell migration during embryonic development
      Title: A Src-Tks5 pathway is required for neural crest cell migration during embryonic development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within posterior lateral line neuromast primordium migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in progesterone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to yeast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    proto-oncogene tyrosine-protein kinase Src
    Names
    pp60c-src
    protein-tyrosine kinase
    proto-oncogene c-Src
    v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
    NP_001003837.2
    XP_005174187.1
    XP_017209008.1
    XP_017209009.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003837.2 → NP_001003837.2  proto-oncogene tyrosine-protein kinase Src

      See identical proteins and their annotated locations for NP_001003837.2

      Status: PROVISIONAL

      Source sequence(s)
      BC116544
      UniProtKB/Swiss-Prot
      Q1JPZ3, Q6EWH0
      UniProtKB/TrEMBL
      B2GS52
      Related
      ENSDARP00000093618.4, ENSDART00000102843.5
      Conserved Domains (4) summary
      cd10365
      Location:145 → 245
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd05071
      Location:258 → 534
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:268 → 517
      Pkinase_Tyr; Protein tyrosine kinase
      cl17036
      Location:85 → 142
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      39346930..39455070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353519.3 → XP_017209008.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      UniProtKB/Swiss-Prot
      Q1JPZ3, Q6EWH0
      UniProtKB/TrEMBL
      A0A8M6Z3N7

    2. XM_005174130.5 → XP_005174187.1  proto-oncogene tyrosine-protein kinase Src isoform X3

      UniProtKB/Swiss-Prot
      Q1JPZ3, Q6EWH0
      UniProtKB/TrEMBL
      A0A2R8QE56, A0A8M2BLD8
      Related
      ENSDARP00000152013.1, ENSDART00000190985.1
      Conserved Domains (4) summary
      cd10365
      Location:151 → 251
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd05071
      Location:264 → 540
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:274 → 523
      Pkinase_Tyr; Protein tyrosine kinase
      cl17036
      Location:85 → 148
      SH3; Src Homology 3 domain superfamily

    3. XM_017353520.3 → XP_017209009.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      Q1JPZ3, Q6EWH0
      UniProtKB/TrEMBL
      A0A8M6YVT4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1JPZ3.2 GenPept UniProtKB/Swiss-Prot:Q1JPZ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.