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    yes1 YES proto-oncogene 1, Src family tyrosine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 407620, updated on 14-Nov-2024

    Summary

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    Official Symbol
    yes1provided by ZNC
    Official Full Name
    YES proto-oncogene 1, Src family tyrosine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050126-1
    See related
    Ensembl:ENSDARG00000005941 AllianceGenome:ZFIN:ZDB-GENE-050126-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    c-yes; p61-Yes
    Summary
    Enables protein tyrosine kinase activity. Acts upstream of or within several processes, including adherens junction maintenance; convergent extension involved in gastrulation; and protein autophosphorylation. Predicted to be located in several cellular components, including anchoring junction; centrosome; and cytosol. Predicted to be active in plasma membrane. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See yes1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31308547..31363407)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31325329..31380189)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487898 Neighboring gene uncharacterized LOC101885430 Neighboring gene adenylate cyclase activating polypeptide 1b Neighboring gene clusterin-like 1 (retinal) Neighboring gene collectin sub-family member 12 Neighboring gene transmembrane protein 236 Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo. Sempou E, et al. Mol Neurodegener, 2016 Feb 9. PMID 26860872, Free PMC Article
    2. Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. Lemeer S, et al. PLoS One, 2007 Jul 4. PMID 17611617, Free PMC Article
    3. Role of Yes kinase during early zebrafish development. Tsai WB, et al. Dev Biol, 2005 Jan 1. PMID 15572145
    4. Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. Yoo SK, et al. J Cell Biol, 2012 Oct 15. PMID 23045550, Free PMC Article
    5. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Huang H, et al. Development, 2007 Mar. PMID 17293535

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adherens junction maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase yes
    Names
    protein-tyrosine kinase
    v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
    yes-kinase
    NP_001013288.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013270.3 → NP_001013288.2  tyrosine-protein kinase yes

      See identical proteins and their annotated locations for NP_001013288.2

      Status: PROVISIONAL

      Source sequence(s)
      BC128657
      UniProtKB/Swiss-Prot
      A1A5H8, Q6EWH1, Q8AXW6
      Related
      ENSDARP00000009659.6, ENSDART00000027090.7
      Conserved Domains (3) summary
      cd09933
      Location:157 → 256
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:97 → 154
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:267 → 545
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      31308547..31363407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A5H8.1 GenPept UniProtKB/Swiss-Prot:A1A5H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.