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    slc7a3a solute carrier family 7 member 3a [ Danio rerio (zebrafish) ]

    Gene ID: 492363, updated on 14-Nov-2024

    Summary

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    Official Symbol
    slc7a3aprovided by ZNC
    Official Full Name
    solute carrier family 7 member 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-206
    See related
    Ensembl:ENSDARG00000020645 AllianceGenome:ZFIN:ZDB-GENE-041114-206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slc7a3; zgc:92563; wu:fc11h09
    Summary
    Predicted to enable L-arginine transmembrane transporter activity; L-lysine transmembrane transporter activity; and L-ornithine transmembrane transporter activity. Acts upstream of or within fatty acid metabolic process and triglyceride metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head. Used to study lipid storage disease and metabolic dysfunction-associated steatotic liver disease. Orthologous to human SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See slc7a3a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30502002..30537411)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30465307..30500716)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 12 Neighboring gene uncharacterized LOC137488828 Neighboring gene RAB39B, member RAS oncogene family a Neighboring gene RAB38c, member of RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The cationic amino acid exporter Slc7a7 is induced and vital in zebrafish tissue macrophages with sustained efferocytic activity. Demy DL, et al. J Cell Sci, 2020 Oct 22. PMID 32973110
    2. Generation and characterization of a transgenic zebrafish expressing the reverse tetracycline transactivator. Gu Q, et al. J Genet Genomics, 2013 Oct 20. PMID 24156918
    3. Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Gu Q, et al. Hepatology, 2014 Dec. PMID 25130427
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. null mutants have hepatic steatosis
      Title: Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 7, member 3
    Names
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007329.2 → NP_001007330.2  solute carrier family 7, member 3

      Status: VALIDATED

      Source sequence(s)
      CT025910
      UniProtKB/TrEMBL
      A0A8M1N377, F1R9X0
      Related
      ENSDARP00000043726.7, ENSDART00000043727.8
      Conserved Domains (2) summary
      TIGR00906
      Location:4 → 611
      2A0303; cationic amino acid transport permease
      pfam13906
      Location:559 → 609
      AA_permease_C; C-terminus of AA_permease

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      30502002..30537411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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