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    lamb1a laminin, beta 1a [ Danio rerio (zebrafish) ]

    Gene ID: 286830, updated on 14-Nov-2024

    Summary

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    Official Symbol
    lamb1aprovided by ZNC
    Official Full Name
    laminin, beta 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021226-1
    See related
    Ensembl:ENSDARG00000101209 AllianceGenome:ZFIN:ZDB-GENE-021226-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gup; cb95; lamb1; fc20b05; sb:cb95; wu:fc20b05
    Summary
    Enables mechanoreceptor activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; determination of left/right asymmetry in lateral mesoderm; and nervous system development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of laminin complex. Is expressed in several structures, including digestive system; eye; fin; heart; and optic cup. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lamb1a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (31546828..31629095, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (31135867..31218134, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene zgc:172145 Neighboring gene myogenic differentiation 1 Neighboring gene laminin, beta 4 Neighboring gene acyl-CoA thioesterase 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Time-lapse analysis and mathematical characterization elucidate novel mechanisms underlying muscle morphogenesis. Snow CJ, et al. PLoS Genet, 2008 Oct 3. PMID 18833302, Free PMC Article
    2. Laminin beta1 and gamma1 containing laminins are essential for basement membrane integrity in the zebrafish eye. Lee J, et al. Invest Ophthalmol Vis Sci, 2007 Jun. PMID 17525174
    3. Zebrafish mutants identify an essential role for laminins in notochord formation. Parsons MJ, et al. Development, 2002 Jul. PMID 12070089
    4. Impaired retinal differentiation and maintenance in zebrafish laminin mutants. Biehlmaier O, et al. Invest Ophthalmol Vis Sci, 2007 Jun. PMID 17525225
    5. Precocious acquisition of neuroepithelial character in the eye field underlies the onset of eye morphogenesis. Ivanovitch K, et al. Dev Cell, 2013 Nov 11. PMID 24209576, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transient induction of lamb1a in epithelial cells is a key, growth factor-guided step in formation of a signaling-competent regeneration epidermis.
      Title: Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration.
    2. Data show that lamb1a regulates asymmetric left-right gene expression in the lateral plate mesoderm (LPM).
      Title: Laminin β1a controls distinct steps during the establishment of digestive organ laterality.
    3. Two zebrafish loci, grumpy and sleepy, encode laminin beta1 and laminin gamma1, respectively. These genes are required for the formation of the laminin-dependent basement membrane is essential for the differentiation of chordamesoderm to notochord.
      Title: Zebrafish mutants identify an essential role for laminins in notochord formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mechanoreceptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in basement membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hypochord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within notochord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within notochord formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within optokinetic behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of laminin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    laminin subunit beta-1a
    Names
    grumpy
    laminin, beta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173275.1 → NP_775382.1  laminin subunit beta-1a precursor

      See identical proteins and their annotated locations for NP_775382.1

      Status: PROVISIONAL

      Source sequence(s)
      AF468049
      UniProtKB/TrEMBL
      Q8JHV7
      Related
      ENSDARP00000131540.2, ENSDART00000170673.2
      Conserved Domains (12) summary
      smart00180
      Location:769 → 814
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG1340
      Location:1441 → 1730
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00055
      Location:394 → 452
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:817 → 865
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:40 → 266
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam01442
      Location:1246 → 1393
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam04156
      Location:1697 → 1774
      IncA; IncA protein
      pfam04871
      Location:1672 → 1774
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      cl00143
      Location:1256 → 1374
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cl00223
      Location:1530 → 1611
      NusB_Sun; RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the ...
      cl14880
      Location:552 → 612
      CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily
      cl23763
      Location:1448 → 1630
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      31546828..31629095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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