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    slc39a5 solute carrier family 39 member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 561758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc39a5provided by ZNC
    Official Full Name
    solute carrier family 39 member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060608-1
    See related
    Ensembl:ENSDARG00000079525 AllianceGenome:ZFIN:ZDB-GENE-060608-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc74g12
    Summary
    Predicted to enable monoatomic cation:bicarbonate symporter activity and zinc ion transmembrane transporter activity. Acts upstream of or within angiogenesis and intracellular zinc ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in gut and head. Human ortholog(s) of this gene implicated in myopia. Orthologous to human SLC39A5 (solute carrier family 39 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc39a5 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (32335871..32352180)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (32409238..32425649)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, alpha a Neighboring gene ring finger protein 41 Neighboring gene ankyrin repeat domain 52a Neighboring gene si:ch211-66i15.4 Neighboring gene TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Slc39a5-mediated zinc homeostasis plays an essential role in venous angiogenesis in zebrafish. Xia Z, et al. Open Biol, 2020 Oct. PMID 33081634, Free PMC Article
    2. Slc39a7/zip7 plays a critical role in development and zinc homeostasis in zebrafish. Yan G, et al. PLoS One, 2012. PMID 22912764, Free PMC Article
    3. Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters. Kambe T, et al. Genomics Proteomics Bioinformatics, 2006 Feb. PMID 16689696, Free PMC Article
    4. The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. He X, et al. Adv Sci (Weinh), 2023 Jun. PMID 37068188, Free PMC Article
    5. SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Zhao L, et al. Biochem Biophys Res Commun, 2019 Apr 16. PMID 30851936

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc transporter ZIP5; LOW QUALITY PROTEIN: zinc transporter ZIP5
    Names
    ZIP5
    solute carrier family 39 (zinc transporter), member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      32335871..32352180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_685166.9 → XP_690258.4  LOW QUALITY PROTEIN: zinc transporter ZIP5

      UniProtKB/Swiss-Prot
      P0DX17
      Related
      ENSDARP00000123704.1, ENSDART00000149698.2

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395161.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      304631..318031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473734.2 → XP_021329409.2  LOW QUALITY PROTEIN: zinc transporter ZIP5

      UniProtKB/Swiss-Prot
      P0DX17
    Nucleotide Protein Strain
    Heading Accession and Version

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