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    max myc associated factor X [ Danio rerio (zebrafish) ]

    Gene ID: 30467, updated on 2-Nov-2024

    Summary

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    Official Symbol
    maxprovided by ZNC
    Official Full Name
    myc associated factor Xprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-152
    See related
    Ensembl:ENSDARG00000024844 AllianceGenome:ZFIN:ZDB-GENE-990415-152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zmax; fa92b04; fb52a04; fb95h11; wu:fa92b04; wu:fb52a04; wu:fb95h11
    Summary
    Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within determination of ventral identity and hemopoiesis. Part of SMAD protein complex. Is expressed in central nervous system and telencephalon. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See max in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (28832760..28842556, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (28929881..28939711, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation-associated 1 like 1 Neighboring gene RAB15, member RAS oncogene family Neighboring gene farnesyltransferase, CAAX box, subunit beta Neighboring gene rho GTPase-activating protein 1-like Neighboring gene solute carrier family 10 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1. Schreiber-Agus N, et al. Oncogene, 1994 Nov. PMID 7936639
    2. Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin. Kelly GM, et al. Mech Dev, 1995 Oct. PMID 8562427
    3. Maternal and embryonic expression of zebrafish lef1. Dorsky RI, et al. Mech Dev, 1999 Aug. PMID 10446273
    4. Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo. Ungar AR, et al. Mech Dev, 1995 Aug. PMID 8541205
    5. Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Erter CE, et al. Dev Biol, 1998 Dec 15. PMID 9882476

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of ventral identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of ventral identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMAD protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein max

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131220.1 → NP_571295.1  protein max

      See identical proteins and their annotated locations for NP_571295.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066760
      UniProtKB/Swiss-Prot
      P52161
      UniProtKB/TrEMBL
      A0A8M1PBI0, Q6NY29
      Related
      ENSDARP00000111552.2, ENSDART00000129858.4
      Conserved Domains (2) summary
      pfam00010
      Location:24 → 75
      HLH; Helix-loop-helix DNA-binding domain
      cl01090
      Location:81 → 103
      SlyX; SlyX

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      28832760..28842556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160621.5 → XP_005160678.1  protein max isoform X3

      UniProtKB/Swiss-Prot
      P52161
      UniProtKB/TrEMBL
      A0A8M2B7H4, Q5SPG2
      Related
      ENSDARP00000119638.1, ENSDART00000137425.3
      Conserved Domains (2) summary
      pfam00010
      Location:15 → 66
      HLH; Helix-loop-helix DNA-binding domain
      cl01090
      Location:72 → 94
      SlyX; SlyX

    2. XM_005160620.5 → XP_005160677.1  protein max isoform X2

      See identical proteins and their annotated locations for XP_005160677.1

      UniProtKB/Swiss-Prot
      P52161
      UniProtKB/TrEMBL
      F6NWG4, F6PAS2, Q803J7
      Related
      ENSDARP00000046034.5, ENSDART00000046035.7
      Conserved Domains (2) summary
      pfam00010
      Location:15 → 71
      HLH; Helix-loop-helix DNA-binding domain
      cl01090
      Location:77 → 99
      SlyX; SlyX

    3. XM_005160619.5 → XP_005160676.1  protein max isoform X1

      UniProtKB/Swiss-Prot
      P52161
      UniProtKB/TrEMBL
      A0A8M2B7R2
      Related
      ENSDART00000132119.2
      Conserved Domains (2) summary
      pfam00010
      Location:24 → 80
      HLH; Helix-loop-helix DNA-binding domain
      cl01090
      Location:86 → 108
      SlyX; SlyX
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52161.1 GenPept UniProtKB/Swiss-Prot:P52161

    Gene LinkOut

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