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    trim55a tripartite motif containing 55a [ Danio rerio (zebrafish) ]

    Gene ID: 436631, updated on 2-Nov-2024

    Summary

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    Official Symbol
    trim55aprovided by ZNC
    Official Full Name
    tripartite motif containing 55aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-50
    See related
    Ensembl:ENSDARG00000029596 AllianceGenome:ZFIN:ZDB-GENE-040718-50
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    trim55; zgc:92123; wu:fb71c01
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in heart contraction. Predicted to be active in cytoplasm. Is expressed in adaxial cell; gonad; heart; musculature system; and somite. Orthologous to human TRIM55 (tripartite motif containing 55). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See trim55a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (42114310..42128660, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (42264892..42279242, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase iron containing 1 Neighboring gene corticoliberin-1 Neighboring gene cytochrome P450, family 7, subfamily B, polypeptide 1 Neighboring gene solute carrier family 39 member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic and functional implications of an exonic TRIM55 variant in heart failure. Heliste J, et al. J Mol Cell Cardiol, 2020 Jan. PMID 31866377
    2. The vertebrate muscle-specific RING finger protein family includes MuRF4--a novel, conserved E3-ubiquitin ligase. Macqueen DJ, et al. FEBS Lett, 2014 Nov 28. PMID 25448676
    3. Generation of MuRF-GFP transgenic zebrafish models for investigating murf gene expression and protein localization in Smyd1b and Hsp90α1 knockdown embryos. Li B, et al. Comp Biochem Physiol B Biochem Mol Biol, 2020 Feb. PMID 31669374, Free PMC Article
    4. Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy. Li M, et al. J Gen Physiol, 2016 Apr. PMID 27022191, Free PMC Article
    5. The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. Shimizu H, et al. Elife, 2017 Aug 19. PMID 28826496, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 55a
    Names
    MuRF2a
    tripartite motif-containing 55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002358.1 → NP_001002358.1  tripartite motif-containing protein 55a

      See identical proteins and their annotated locations for NP_001002358.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075897
      UniProtKB/TrEMBL
      A0A8M1N0B2, Q6DHS0
      Related
      ENSDARP00000047054.6, ENSDART00000047055.7
      Conserved Domains (3) summary
      smart00336
      Location:122 → 159
      BBOX; B-Box-type zinc finger
      cd00162
      Location:25 → 84
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam04437
      Location:216 → 296
      RINT1_TIP1; RINT-1 / TIP-1 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      42114310..42128660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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