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    rbx1 ring-box 1, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 449846, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rbx1provided by ZNC
    Official Full Name
    ring-box 1, E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041008-106
    See related
    Ensembl:ENSDARG00000038030 AllianceGenome:ZFIN:ZDB-GENE-041008-106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7137515; zgc:136444
    Summary
    Predicted to enable cullin family protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within ventricular trabecula myocardium morphogenesis. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in female organism. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rbx1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25101960..25107802, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (24971412..24977254, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene X-prolyl aminopeptidase 3, mitochondrial Neighboring gene ST13 Hsp70 interacting protein Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene chondroadherin-like a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish. Sarvari P, et al. Dev Biol, 2021 Dec. PMID 34363825
    2. Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos. Rauwerda H, et al. BMC Genomics, 2017 Apr 11. PMID 28399811, Free PMC Article
    3. Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae. Long Y, et al. BMC Genomics, 2015 May 15. PMID 25975375, Free PMC Article
    4. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
    5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish.
      Title: The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RBX1
    NP_001077013.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083544.1 → NP_001077013.1  E3 ubiquitin-protein ligase RBX1

      See identical proteins and their annotated locations for NP_001077013.1

      Status: VALIDATED

      Source sequence(s)
      BX470254
      UniProtKB/TrEMBL
      A0A8M1NDS7, A4FUL3
      Related
      ENSDARP00000055431.6, ENSDART00000055432.8
      Conserved Domains (1) summary
      cd16485
      Location:40 → 101
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      25101960..25107802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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