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    edc4 enhancer of mRNA decapping 4 [ Danio rerio (zebrafish) ]

    Gene ID: 565659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    edc4provided by ZNC
    Official Full Name
    enhancer of mRNA decapping 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5032
    See related
    Ensembl:ENSDARG00000062266 AllianceGenome:ZFIN:ZDB-GENE-030131-5032
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe26b05; wu:fe26b05; si:ch211-237c7.1
    Summary
    Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to be located in cytoplasm and nucleus. Predicted to be active in P-body. Orthologous to human EDC4 (enhancer of mRNA decapping 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See edc4 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (21860517..21912228, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (21871451..21923162, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene protein serine kinase H1 Neighboring gene neuritin 1-like a Neighboring gene nuclear transport factor 2 Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene RAN binding protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within deadenylation-independent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of mRNA-decapping protein 4
    Names
    autoantigen RCD8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045085.1 → NP_001038550.1  enhancer of mRNA-decapping protein 4

      See identical proteins and their annotated locations for NP_001038550.1

      Status: PROVISIONAL

      Source sequence(s)
      BX927240
      UniProtKB/Swiss-Prot
      Q1LUT1
      Related
      ENSDARP00000130250.1, ENSDART00000169220.2
      Conserved Domains (3) summary
      pfam16529
      Location:112 → 437
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:177 → 216
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:169 → 400
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      21860517..21912228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293574.3 → XP_009291849.1  enhancer of mRNA-decapping protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AJJ8
      Related
      ENSDARP00000148991.1, ENSDART00000191764.1
      Conserved Domains (3) summary
      pfam16529
      Location:112 → 437
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:177 → 216
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:169 → 400
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_021467677.2 → XP_021323352.1  enhancer of mRNA-decapping protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M9P146
      Related
      ENSDARP00000084220.5, ENSDART00000089787.6
      Conserved Domains (3) summary
      sd00039
      Location:177 → 216
      7WD40; WD40 repeat [structural motif]
      pfam16529
      Location:112 → 448
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      cl25548
      Location:829 → 1012
      DUF4670; Domain of unknown function (DUF4670)

    3. XM_021467676.2 → XP_021323351.1  enhancer of mRNA-decapping protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM70
      Conserved Domains (3) summary
      sd00039
      Location:177 → 216
      7WD40; WD40 repeat [structural motif]
      pfam16529
      Location:112 → 448
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      cl25548
      Location:869 → 1052
      DUF4670; Domain of unknown function (DUF4670)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395341.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      228402..279126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LUT1.1 GenPept UniProtKB/Swiss-Prot:Q1LUT1

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