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    gtpbp4 GTP binding protein 4 [ Danio rerio (zebrafish) ]

    Gene ID: 334050, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gtpbp4provided by ZNC
    Official Full Name
    GTP binding protein 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5982
    See related
    Ensembl:ENSDARG00000018961 AllianceGenome:ZFIN:ZDB-GENE-030131-5982
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi28d07; zgc:55757; wu:fi28d07
    Summary
    Predicted to enable GTPase activity and RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in gill. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gtpbp4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (42361373..42375233, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (42511955..42525815, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin/ISG15 ligase TRIM25-like Neighboring gene si:dkey-7l6.3 Neighboring gene solute carrier organic anion transporter family member 5A1a Neighboring gene solute carrier organic anion transporter family member 5A1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of hypothermia on gene expression in zebrafish gills: upregulation in differentiation and function of ionocytes as compensatory responses. Chou MY, et al. J Exp Biol, 2008 Oct. PMID 18805806
    2. New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. Tseng LC, et al. PLoS One, 2014. PMID 24714733, Free PMC Article
    3. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein 4
    Names
    G protein-binding protein CRFG
    GTP binding protein NGB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199851.1 → NP_956145.1  GTP-binding protein 4

      See identical proteins and their annotated locations for NP_956145.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045447
      UniProtKB/TrEMBL
      Q7ZVR0
      Related
      ENSDARP00000002061.4, ENSDART00000026339.5
      Conserved Domains (3) summary
      cd01897
      Location:169 → 340
      NOG; Nucleolar GTP-binding protein (NOG)
      COG1084
      Location:5 → 343
      Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
      pfam08155
      Location:396 → 446
      NOGCT; NOGCT (NUC087) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      42361373..42375233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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