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    faxdc2 fatty acid hydroxylase domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406828, updated on 2-Nov-2024

    Summary

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    Official Symbol
    faxdc2provided by ZNC
    Official Full Name
    fatty acid hydroxylase domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2907
    See related
    Ensembl:ENSDARG00000023820 AllianceGenome:ZFIN:ZDB-GENE-040426-2907
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55420; wu:fc21b10
    Summary
    Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to act upstream of or within lipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human FAXDC2 (fatty acid hydroxylase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See faxdc2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45788028..45852112)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (45802099..45813782)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101883451 Neighboring gene macroH2A.1 histone Neighboring gene paired-like homeodomain 1 Neighboring gene uncharacterized LOC137488853 Neighboring gene thioredoxin domain containing 15 Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene sap30-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid hydroxylase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213507.1 → NP_998672.1  fatty acid hydroxylase domain-containing protein 2

      See identical proteins and their annotated locations for NP_998672.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044395
      UniProtKB/TrEMBL
      A0A8M1PQB9, Q803P4
      Related
      ENSDARP00000035841.6, ENSDART00000038657.7
      Conserved Domains (2) summary
      COG3000
      Location:159 → 288
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:164 → 288
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      45788028..45852112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215831.1 → XP_068071932.1  fatty acid hydroxylase domain-containing protein 2 isoform X1

      Related
      ENSDARP00000154694.1, ENSDART00000189305.1
    Nucleotide Protein Strain
    Heading Accession and Version

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